CAMKK2

Entrez Summary: The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
PT-1 25μM R07 exp392	1.84
Dimethyl-Sulfoxide 1pc R03 exp120	2.21

Pkinase
Pkinase Tyr

CAMKK-AMPK signaling cascade
calmodulin dependent kinase signaling pathway
positive regulation of autophagy of mitochondrion
calmodulin-dependent protein kinase activity
regulation of autophagy of mitochondrion
protein tyrosine kinase activity
cell projection
positive regulation of mitochondrion organization
positive regulation of autophagy
cellular response to reactive oxygen species
peptidyl-tyrosine phosphorylation
calcium-mediated signaling
peptidyl-tyrosine modification
regulation of mitochondrion organization
protein autophosphorylation
response to reactive oxygen species
calmodulin binding
cellular response to oxidative stress
regulation of autophagy
second-messenger-mediated signaling
positive regulation of cellular catabolic process
MAPK cascade
response to oxidative stress
signal transduction by protein phosphorylation
positive regulation of catabolic process
positive regulation of organelle organization
calcium ion binding
regulation of protein kinase activity
regulation of cellular catabolic process
regulation of kinase activity
peptidyl-amino acid modification
protein phosphorylation
regulation of transferase activity
regulation of catabolic process
positive regulation of protein phosphorylation
cellular response to oxygen-containing compound
positive regulation of phosphorylation
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
positive regulation of cellular component organization