CAMLG

Gene Information

Official Symbol: CAMLG
Official Name: calcium modulating ligand
Aliases and Previous Symbols: N/A
Entrez ID: 819
UniProt: P49069
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CCCP 0.1μM R00 exp10	-2.72
2-Methoxyestradiol 0.2μM R01 exp40	-2.38
UM131593 0.1μM R01 exp58	-1.99
ABT-702 5μM R07 exp318	-1.85
Celastrol 0.12μM R05 exp225	-1.85
Golgicide-A 2μM R03 exp121	-1.82
A-395N 10μM R05 exp219	-1.71

Global Fraction of Cell Lines Where Essential: 8/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	2/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3566
Expression level (log2 read counts): 4.58

Expression Distribution

Gene	Correlation
GEMIN7	0.416
WRB	0.402

receptor recycling
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of ubiquitin-dependent protein catabolic process
epidermal growth factor receptor signaling pathway
negative regulation of proteasomal protein catabolic process
cell adhesion molecule binding
ERBB signaling pathway
negative regulation of proteolysis involved in cellular protein catabolic process
negative regulation of protein ubiquitination
negative regulation of protein modification by small protein conjugation or removal
negative regulation of cellular protein catabolic process
receptor metabolic process
regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of protein catabolic process
regulation of ubiquitin-dependent protein catabolic process
protein stabilization
regulation of proteasomal protein catabolic process
regulation of protein ubiquitination
regulation of proteolysis involved in cellular protein catabolic process
regulation of protein modification by small protein conjugation or removal
regulation of cellular protein catabolic process
negative regulation of cellular catabolic process
regulation of protein stability
ubiquitin protein ligase binding
negative regulation of catabolic process
negative regulation of proteolysis
regulation of protein catabolic process
transmembrane receptor protein tyrosine kinase signaling pathway
negative regulation of protein modification process
viral process
enzyme linked receptor protein signaling pathway
regulation of proteolysis
symbiotic process
interspecies interaction between organisms
regulation of cellular catabolic process
regulation of catabolic process
endoplasmic reticulum
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
defense response