CARD16

Gene Information

Official Symbol: CARD16
Official Name: caspase recruitment domain family member 16
Aliases and Previous Symbols: N/A
Entrez ID: 114769
UniProt: Q5EG05
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Caspase inhibitor. Acts as a regulator of procaspase- 1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro- inflammatory cytokine response. Also able to inhibit CASP1- mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. {ECO:0000269|PubMed:11432859, ECO:0000269|PubMed:11536016, ECO:0000269|PubMed:16920334}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13482
Expression level (log2 read counts): -0.15

Expression Distribution

Screen	Score
CI-1040 9.5μM R08 exp472	-1.79
Epothilone-B 0.0015μM R05 exp231	1.73
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	2.29

protease inhibitor complex
cellular response to UV-C
caspase binding
inhibition of cysteine-type endopeptidase activity
zymogen inhibition
negative regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of interleukin-1 beta secretion
CARD domain binding
response to UV-C
negative regulation of interleukin-1 secretion
negative regulation of tumor necrosis factor-mediated signaling pathway
regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of interleukin-1 beta production
negative regulation of protein maturation
cysteine-type endopeptidase inhibitor activity
negative regulation of interleukin-1 production
negative regulation of protein processing
regulation of interleukin-1 beta secretion
regulation of interleukin-1 secretion
regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of cytokine-mediated signaling pathway
negative regulation of response to cytokine stimulus
regulation of protein processing
regulation of protein maturation
negative regulation of cytokine secretion
regulation of interleukin-1 beta production
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
cellular response to UV
negative regulation of cysteine-type endopeptidase activity
kinase binding
negative regulation of response to biotic stimulus
regulation of interleukin-1 production
negative regulation of protein binding
cellular response to light stimulus
negative regulation of protein secretion
negative regulation of peptide secretion
response to UV
positive regulation of NF-kappaB transcription factor activity
regulation of cytokine-mediated signaling pathway
negative regulation of binding