CATSPER2

Entrez Summary: This gene encodes a member of a family of cation channel proteins that localize to the flagellum of spermatozoa. Defects at this locus causes male infertility. Alternatively spliced transcript variants have been observed at this locus. Readthrough transcription originates upstream of this locus in diphosphoinositol pentakisphosphate kinase 1 pseudogene 1 and is represented by GeneID:110006325. Related pseudogenes are found next to this locus on chromosome 15 and on chromosome 5. [provided by RefSeq, Mar 2017].
UniProt Summary: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

CatSper complex
calcium activated cation channel activity
sperm capacitation
voltage-gated ion channel activity
response to progesterone
sperm-egg recognition
calcium channel activity
cell-cell recognition
sperm motility
flagellated sperm motility
cilium-dependent cell motility
cilium or flagellum-dependent cell motility
motile cilium
single fertilization
spermatid development
spermatid differentiation
cell maturation
fertilization
response to ketone
calcium ion transmembrane transport
cell recognition
developmental maturation
calcium ion transport
germ cell development
divalent metal ion transport
divalent inorganic cation transport
response to steroid hormone
cellular process involved in reproduction in multicellular organism
regulation of ion transmembrane transport
spermatogenesis
inorganic cation transmembrane transport
regulation of transmembrane transport
male gamete generation
cation transmembrane transport
metal ion transport
inorganic ion transmembrane transport
developmental process involved in reproduction
gamete generation
regulation of ion transport
multicellular organismal reproductive process