CBR3

Entrez Summary: Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. [provided by RefSeq, Jul 2008].
UniProt Summary: Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro). {ECO:0000269|PubMed:18493841}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

adh short
KR

quinone catabolic process
phylloquinone catabolic process
phylloquinone metabolic process
carbonyl reductase (NADPH) activity
3-keto sterol reductase activity
ketone catabolic process
vitamin catabolic process
NADPH binding
coenzyme catabolic process
quinone metabolic process
cofactor catabolic process
cellular ketone metabolic process
vitamin metabolic process
xenobiotic metabolic process
cellular response to xenobiotic stimulus
coenzyme metabolic process
cognition
response to xenobiotic stimulus
small molecule catabolic process
cofactor metabolic process
oxidation-reduction process
nervous system process
extracellular space
small molecule metabolic process
organic substance catabolic process
cellular catabolic process
system process