CBR4

Entrez Summary: N/A
UniProt Summary: The heterotetramer with HSD17B8 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis (PubMed:19571038, PubMed:25203508). Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD (PubMed:25203508). The homotetramer has NADPH-dependent quinone reductase activity (PubMed:19000905). Both homotetramer and the heterotetramer have broad substrate specificity and can reduce 9,10- phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro) (PubMed:19000905, PubMed:19571038, PubMed:25203508). {ECO:0000269|PubMed:19000905, ECO:0000269|PubMed:19571038, ECO:0000269|PubMed:25203508}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Nifuroxazide 1μM R01 exp51	1.72
THZ531 0.225μM R08 exp444	1.8

KR
adh short

NADPH dehydrogenase (quinone) activity
oxidoreductase complex
3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity
NAD(P)H dehydrogenase (quinone) activity
daunorubicin metabolic process
doxorubicin metabolic process
polyketide metabolic process
aminoglycoside antibiotic metabolic process
quinone binding
tertiary alcohol metabolic process
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
NADPH binding
glycoside metabolic process
quinone metabolic process
protein heterotetramerization
fatty-acyl-CoA biosynthetic process
fatty-acyl-CoA metabolic process
acyl-CoA biosynthetic process
thioester biosynthetic process
secondary metabolic process
ribonucleoside bisphosphate biosynthetic process
nucleoside bisphosphate biosynthetic process
purine nucleoside bisphosphate biosynthetic process
cellular ketone metabolic process
primary alcohol metabolic process
fatty acid derivative biosynthetic process
protein homotetramerization
thioester metabolic process
acyl-CoA metabolic process
antibiotic metabolic process
protein heterooligomerization
fatty acid biosynthetic process
nucleoside bisphosphate metabolic process
purine nucleoside bisphosphate metabolic process
ribonucleoside bisphosphate metabolic process
glycosyl compound metabolic process
coenzyme biosynthetic process
purine ribonucleotide biosynthetic process
protein tetramerization
purine nucleotide biosynthetic process