CCL1
Gene Information
- Official Symbol: CCL1
- Official Name: C-C motif chemokine ligand 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 6346
- UniProt: P22362
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8. {ECO:0000269|PubMed:1557400}.
Pfam Domains GO Terms
Pfam Domains
| IL8 |
GO Terms
| positive regulation of interleukin-17 secretion |
| regulation of interleukin-17 secretion |
| positive regulation of interleukin-17 production |
| positive regulation of monocyte chemotaxis |
| eosinophil chemotaxis |
| eosinophil migration |
| positive regulation of mononuclear cell migration |
| regulation of monocyte chemotaxis |
| CCR chemokine receptor binding |
| regulation of interleukin-17 production |
| monocyte chemotaxis |
| regulation of mononuclear cell migration |
| lymphocyte chemotaxis |
| mononuclear cell migration |
| chemokine activity |
| lymphocyte migration |
| chemokine-mediated signaling pathway |
| cell |
| neutrophil chemotaxis |
| positive regulation of leukocyte chemotaxis |
| granulocyte chemotaxis |
| cellular response to chemokine |
| response to chemokine |
| neutrophil migration |
| granulocyte migration |
| regulation of leukocyte chemotaxis |
| myeloid leukocyte migration |
| positive regulation of leukocyte migration |
| positive regulation of chemotaxis |
| positive regulation of cytokine secretion |
| positive regulation of inflammatory response |
| leukocyte chemotaxis |
| cellular response to interferon-gamma |
| cellular response to interleukin-1 |
| response to interferon-gamma |
| regulation of leukocyte migration |
| response to interleukin-1 |
| regulation of cytokine secretion |
| cell chemotaxis |
| positive regulation of ERK1 and ERK2 cascade |
| regulation of chemotaxis |
| cellular response to tumor necrosis factor |
| response to tumor necrosis factor |
| positive regulation of protein secretion |
| positive regulation of cytosolic calcium ion concentration |
| positive regulation of peptide secretion |
| regulation of ERK1 and ERK2 cascade |
| regulation of cytosolic calcium ion concentration |
| regulation of inflammatory response |
| leukocyte migration |
| positive regulation of secretion by cell |
| positive regulation of GTPase activity |
| positive regulation of protein transport |
| positive regulation of secretion |
| cellular calcium ion homeostasis |
| positive regulation of cytokine production |
| calcium ion homeostasis |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| cellular divalent inorganic cation homeostasis |
| positive regulation of defense response |
| regulation of GTPase activity |
| divalent inorganic cation homeostasis |
| regulation of peptide secretion |
| inflammatory response |
| positive regulation of cell migration |
| positive regulation of cell motility |
| positive regulation of cellular component movement |
| positive regulation of MAPK cascade |
| chemotaxis |
| positive regulation of locomotion |
| taxis |
| cellular metal ion homeostasis |
| positive regulation of response to external stimulus |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| cytokine-mediated signaling pathway |
| regulation of cytokine production |
| viral process |
| cation homeostasis |
| regulation of protein transport |
| inorganic ion homeostasis |
| regulation of peptide transport |
| cellular chemical homeostasis |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| regulation of defense response |
| innate immune response |
| positive regulation of hydrolase activity |
| symbiotic process |
| ion homeostasis |
| regulation of secretion |
| interspecies interaction between organisms |
| regulation of cell migration |
| cellular homeostasis |
| regulation of cell motility |
| defense response to other organism |
| cell migration |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| positive regulation of phosphorylation |
| localization of cell |
| cell motility |
| regulation of response to external stimulus |
| response to cytokine |
| chemical homeostasis |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| positive regulation of immune system process |
| positive regulation of protein modification process |
| regulation of hydrolase activity |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| G protein-coupled receptor signaling pathway |
| response to biotic stimulus |
| defense response |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| movement of cell or subcellular component |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of immune system process |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| immune response |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| SB743921 0.001μM R05 exp244 | -2.04 |
| Wiskostatin 3μM R07 exp422 | -1.99 |
| Vemurafenib 6.6μM R02 exp89 | 1.75 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11017
- Expression level (log2 read counts): -7.68
Expression Distribution
CCL1 Expression in NALM6 Cells: -7.68
