CCL7
Gene Information
- Official Symbol: CCL7
- Official Name: C-C motif chemokine ligand 7
- Aliases and Previous Symbols: N/A
- Entrez ID: 6354
- UniProt: P80098
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.
Pfam Domains GO Terms
Pfam Domains
| IL8 |
GO Terms
| CCR2 chemokine receptor binding |
| CCR1 chemokine receptor binding |
| positive regulation of natural killer cell chemotaxis |
| regulation of natural killer cell chemotaxis |
| cellular response to ethanol |
| eosinophil chemotaxis |
| positive regulation of lymphocyte chemotaxis |
| eosinophil migration |
| regulation of lymphocyte chemotaxis |
| CCR chemokine receptor binding |
| positive regulation of lymphocyte migration |
| monocyte chemotaxis |
| lymphocyte chemotaxis |
| mononuclear cell migration |
| chemokine activity |
| response to gamma radiation |
| regulation of lymphocyte migration |
| lymphocyte migration |
| chemokine-mediated signaling pathway |
| cell |
| neutrophil chemotaxis |
| cellular response to alcohol |
| positive regulation of leukocyte chemotaxis |
| granulocyte chemotaxis |
| response to chemokine |
| cellular response to chemokine |
| neutrophil migration |
| granulocyte migration |
| regulation of leukocyte chemotaxis |
| cellular response to antibiotic |
| response to ethanol |
| myeloid leukocyte migration |
| positive regulation of leukocyte migration |
| positive regulation of chemotaxis |
| leukocyte chemotaxis |
| response to ionizing radiation |
| regulation of cell shape |
| cellular response to interferon-gamma |
| heparin binding |
| cellular response to interleukin-1 |
| response to interferon-gamma |
| regulation of leukocyte migration |
| response to interleukin-1 |
| cell chemotaxis |
| positive regulation of ERK1 and ERK2 cascade |
| regulation of chemotaxis |
| cellular response to toxic substance |
| response to alcohol |
| cellular response to tumor necrosis factor |
| response to tumor necrosis factor |
| regulation of ERK1 and ERK2 cascade |
| response to antibiotic |
| leukocyte migration |
| cellular response to drug |
| positive regulation of GTPase activity |
| cellular calcium ion homeostasis |
| response to radiation |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| regulation of GTPase activity |
| regulation of cell morphogenesis |
| divalent inorganic cation homeostasis |
| inflammatory response |
| positive regulation of cell migration |
| response to toxic substance |
| positive regulation of cell motility |
| positive regulation of cellular component movement |
| positive regulation of MAPK cascade |
| chemotaxis |
| positive regulation of locomotion |
| taxis |
| cellular metal ion homeostasis |
| positive regulation of response to external stimulus |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| cytokine-mediated signaling pathway |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| regulation of MAPK cascade |
| innate immune response |
| positive regulation of hydrolase activity |
| ion homeostasis |
| regulation of cell migration |
| cellular homeostasis |
| regulation of cell motility |
| defense response to other organism |
| cell migration |
| regulation of locomotion |
| regulation of cellular component movement |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| response to drug |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| localization of cell |
| cell motility |
| regulation of response to external stimulus |
| response to cytokine |
| cytoskeleton organization |
| chemical homeostasis |
| cell-cell signaling |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| positive regulation of immune system process |
| response to abiotic stimulus |
| positive regulation of protein modification process |
| regulation of hydrolase activity |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| G protein-coupled receptor signaling pathway |
| response to biotic stimulus |
| defense response |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of immune system process |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| immune response |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Menadione 5μM R06 exp292 | -1.89 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17293
- Expression level (log2 read counts): -7.68
Expression Distribution
CCL7 Expression in NALM6 Cells: -7.68
