CCNL2

Entrez Summary: The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process, as well as in inducing apoptosis by modulating the expression of apoptotic and antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]. COMPLETENESS: complete on the 3' end.
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Arsenate 40μM R06 exp264	-2.69
Rotenone 20μM R00 exp34	-2.2
Colchicine 0.009μM R05 exp215	1.7
CCT251545 20μM R07 exp326	1.78
Milciclib 2μM R08 exp502	1.8
Cytochalasin-B 5μM R07 exp349	1.81
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.85
RO-3307 4.7μM R02 exp80	2.03
ML-792 0.2μM R08 exp505	2.27
Bortezomib 0.005μM R00 exp6	2.41

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cyclin-dependent protein serine/threonine kinase regulator activity
regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of cyclin-dependent protein kinase activity
nuclear speck
regulation of protein serine/threonine kinase activity
intracellular membrane-bounded organelle
regulation of protein kinase activity
regulation of kinase activity
regulation of transferase activity
regulation of cell cycle
regulation of protein phosphorylation
regulation of phosphorylation
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process