CCR2
Gene Information
- Official Symbol: CCR2
- Official Name: C-C motif chemokine receptor 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 729230
- UniProt: P41597
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the chemokine receptor gene cluster region of chromosome 3. [provided by RefSeq, Aug 2017].
- UniProt Summary: Receptor for the CCL2, CCL7 and CCL13 chemokines (PubMed:23408426). Receptor for the beta-defensin DEFB106A/DEFB106B (PubMed:23938203). Transduces a signal by increasing intracellular calcium ion levels (By similarity). Upon CCL2 ligation, mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable). {ECO:0000250|UniProtKB:P51683, ECO:0000269|PubMed:23408426, ECO:0000269|PubMed:23938203, ECO:0000305|PubMed:15995708}.
Pfam Domains GO Terms
Pfam Domains
| 7TM GPCR Srsx |
| 7tm 1 |
GO Terms
| chemokine (C-C motif) ligand 2 binding |
| helper T cell chemotaxis |
| positive regulation of immune complex clearance by monocytes and macrophages |
| T-helper 17 cell chemotaxis |
| chemokine (C-C motif) ligand 12 binding |
| positive regulation of astrocyte chemotaxis |
| negative regulation of eosinophil degranulation |
| chemokine (C-C motif) ligand 7 binding |
| regulation of hematopoietic stem cell migration |
| positive regulation of CD8-positive, alpha-beta T cell extravasation |
| regulation of immune complex clearance by monocytes and macrophages |
| positive regulation of hematopoietic stem cell migration |
| negative regulation of eosinophil activation |
| regulation of astrocyte chemotaxis |
| regulation of eosinophil degranulation |
| regulation of CD8-positive, alpha-beta T cell extravasation |
| positive regulation of thymocyte migration |
| positive regulation of T cell extravasation |
| positive regulation of monocyte extravasation |
| positive regulation of leukocyte tethering or rolling |
| regulation of thymocyte migration |
| regulation of eosinophil activation |
| regulation of monocyte extravasation |
| CCR2 chemokine receptor binding |
| neutrophil clearance |
| monocyte extravasation |
| regulation of T cell extravasation |
| positive regulation of NMDA glutamate receptor activity |
| inflammatory response to wounding |
| regulation of leukocyte tethering or rolling |
| positive regulation of glial cell migration |
| neutrophil homeostasis |
| negative regulation of myeloid leukocyte mediated immunity |
| T cell chemotaxis |
| negative regulation of type 2 immune response |
| negative regulation of leukocyte degranulation |
| positive regulation of leukocyte adhesion to vascular endothelial cell |
| regulation of glial cell migration |
| positive regulation of T cell chemotaxis |
| positive regulation of glutamate receptor signaling pathway |
| regulation of T cell chemotaxis |
| chemokine receptor activity |
| positive regulation of cellular extravasation |
| negative regulation of adenylate cyclase activity |
| positive regulation of monocyte chemotaxis |
| dendritic cell chemotaxis |
| leukocyte adhesion to vascular endothelial cell |
| positive regulation of alpha-beta T cell proliferation |
| regulation of leukocyte adhesion to vascular endothelial cell |
| macrophage migration |
| positive regulation of T-helper 1 type immune response |
| negative regulation of cyclase activity |
| positive regulation of tumor necrosis factor biosynthetic process |
| dendritic cell migration |
| positive regulation of lymphocyte chemotaxis |
| negative regulation of lyase activity |
| C-C chemokine receptor activity |
| chemokine binding |
| C-C chemokine binding |
| positive regulation of mononuclear cell migration |
| regulation of monocyte chemotaxis |
| negative regulation of regulated secretory pathway |
| regulation of lymphocyte chemotaxis |
| regulation of T-helper 1 type immune response |
| T cell migration |
| regulation of adenylate cyclase activity |
| regulation of cellular extravasation |
| regulation of tumor necrosis factor biosynthetic process |
| positive regulation of interleukin-2 production |
| regulation of type 2 immune response |
| homeostasis of number of cells within a tissue |
| regulation of alpha-beta T cell proliferation |
| regulation of T cell cytokine production |
| positive regulation of T cell migration |
| regulation of vascular endothelial growth factor production |
| blood vessel remodeling |
| positive regulation of synaptic transmission, glutamatergic |
| negative regulation of exocytosis |
| positive regulation of signaling receptor activity |
| regulation of NMDA receptor activity |
| positive regulation of lymphocyte migration |
| receptor signaling pathway via JAK-STAT |
| cellular extravasation |
| receptor signaling pathway via STAT |
| monocyte chemotaxis |
| regulation of cyclase activity |
| regulation of T cell migration |
| regulation of lyase activity |
| regulation of mononuclear cell migration |
| lymphocyte chemotaxis |
| mononuclear cell migration |
| negative regulation of leukocyte mediated immunity |
| regulation of leukocyte degranulation |
| leukocyte cell-cell adhesion |
| cellular defense response |
| regulation of interleukin-2 production |
| regulation of myeloid leukocyte mediated immunity |
| positive regulation of alpha-beta T cell activation |
| regulation of lymphocyte migration |
| positive regulation of interferon-gamma production |
| regulation of glutamate receptor signaling pathway |
| lymphocyte migration |
| positive regulation of cytokine biosynthetic process |
| positive regulation of gliogenesis |
| leukocyte homeostasis |
| positive regulation of cation channel activity |
| regulation of synaptic transmission, glutamatergic |
| regulation of T cell mediated immunity |
| regulation of neurotransmitter receptor activity |
| sensory perception of pain |
| chemokine-mediated signaling pathway |
| regulation of cytokine production involved in immune response |
| positive regulation of tumor necrosis factor production |
| positive regulation of tumor necrosis factor superfamily cytokine production |
| positive regulation of leukocyte chemotaxis |
| cellular response to chemokine |
| response to chemokine |
| regulation of alpha-beta T cell activation |
| positive regulation of T cell proliferation |
| positive regulation of cold-induced thermogenesis |
| regulation of interferon-gamma production |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| tissue remodeling |
| negative regulation of angiogenesis |
| positive regulation of ion transmembrane transporter activity |
| regulation of cytokine biosynthetic process |
| positive regulation of adaptive immune response |
| negative regulation of blood vessel morphogenesis |
| myeloid cell homeostasis |
| positive regulation of transporter activity |
| regulation of leukocyte chemotaxis |
| negative regulation of vasculature development |
| regulation of gliogenesis |
| negative regulation of immune effector process |
| myeloid leukocyte migration |
| positive regulation of leukocyte migration |
| positive regulation of lymphocyte proliferation |
| positive regulation of mononuclear cell proliferation |
| perikaryon |
| positive regulation of chemotaxis |
| positive regulation of leukocyte proliferation |
| regulation of T cell differentiation |
| positive regulation of inflammatory response |
| regulation of production of molecular mediator of immune response |
| positive regulation of cation transmembrane transport |
| regulation of cold-induced thermogenesis |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| leukocyte chemotaxis |
| calcium-mediated signaling |
| negative regulation of immune response |
| regulation of tumor necrosis factor production |
| regulation of lymphocyte mediated immunity |
| positive regulation of synaptic transmission |
| regulation of tumor necrosis factor superfamily cytokine production |
| positive regulation of ion transmembrane transport |
| regulation of T cell proliferation |
| regulation of adaptive immune response |
| regulation of regulated secretory pathway |
| regulation of lymphocyte differentiation |
| regulation of cation channel activity |
| regulation of signaling receptor activity |
| negative regulation of leukocyte activation |
| tissue homeostasis |
| regulation of leukocyte migration |
| negative regulation of cell activation |
| homeostasis of number of cells |
| positive regulation of transmembrane transport |
| positive regulation of T cell activation |
| negative regulation of secretion by cell |
| regulation of leukocyte mediated immunity |
| regulation of lymphocyte proliferation |
| cell chemotaxis |
| regulation of mononuclear cell proliferation |
| regulation of chemotaxis |
| positive regulation of leukocyte cell-cell adhesion |
| positive regulation of immune effector process |
| regulation of leukocyte proliferation |
| regulation of exocytosis |
| negative regulation of secretion |
| positive regulation of cell-cell adhesion |
| regulation of ion transmembrane transporter activity |
| regulation of transmembrane transporter activity |
| regulation of leukocyte differentiation |
| positive regulation of ion transport |
| regulation of transporter activity |
| positive regulation of cytosolic calcium ion concentration |
| regulation of angiogenesis |
| regulation of leukocyte cell-cell adhesion |
| regulation of T cell activation |
| regulation of vasculature development |
| multicellular organismal homeostasis |
| regulation of cytosolic calcium ion concentration |
| regulation of cation transmembrane transport |
| second-messenger-mediated signaling |
| regulation of inflammatory response |
| anatomical structure homeostasis |
| humoral immune response |
| positive regulation of lymphocyte activation |
| neuronal cell body |
| leukocyte migration |
| external side of plasma membrane |
| regulation of cell-cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of cell adhesion |
| positive regulation of cell activation |
| dendrite |
| cellular calcium ion homeostasis |
| modulation of chemical synaptic transmission |
| negative regulation of immune system process |
| regulation of trans-synaptic signaling |
| positive regulation of cytokine production |
| calcium ion homeostasis |
| regulation of hemopoiesis |
| regulation of immune effector process |
| cellular divalent inorganic cation homeostasis |
| positive regulation of neurogenesis |
| positive regulation of defense response |
| regulation of ion transmembrane transport |
| negative regulation of transport |
| divalent inorganic cation homeostasis |
| inflammatory response |
| positive regulation of cell migration |
| cell-cell adhesion |
| regulation of lymphocyte activation |
| positive regulation of cell motility |
| positive regulation of nervous system development |
| positive regulation of cellular component movement |
| positive regulation of cell development |
| regulation of vesicle-mediated transport |
| chemotaxis |
| taxis |
| positive regulation of locomotion |
| hemopoiesis |
| cellular metal ion homeostasis |
| regulation of transmembrane transport |
| response to wounding |
| regulation of leukocyte activation |
| positive regulation of response to external stimulus |
| hematopoietic or lymphoid organ development |
| metal ion homeostasis |
| cellular cation homeostasis |
| regulation of cell activation |
| cellular ion homeostasis |
| immune system development |
| cytokine-mediated signaling pathway |
| regulation of cell adhesion |
| regulation of cytokine production |
| perinuclear region of cytoplasm |
| regulation of ion transport |
| viral process |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| regulation of secretion by cell |
| regulation of defense response |
| symbiotic process |
| ion homeostasis |
| negative regulation of catalytic activity |
| regulation of secretion |
| regulation of neurogenesis |
| interspecies interaction between organisms |
| regulation of cell migration |
| positive regulation of immune response |
| protein homodimerization activity |
| cellular homeostasis |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| regulation of nervous system development |
| cell adhesion |
| regulation of cell development |
| biological adhesion |
| negative regulation of developmental process |
| cell migration |
| positive regulation of cell differentiation |
| sensory perception |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| cellular response to cytokine stimulus |
| regulation of anatomical structure morphogenesis |
| cell motility |
| localization of cell |
| regulation of response to external stimulus |
| response to cytokine |
| chemical homeostasis |
| negative regulation of molecular function |
| regulation of immune response |
| positive regulation of immune system process |
| negative regulation of multicellular organismal process |
| locomotion |
| G protein-coupled receptor signaling pathway |
| defense response |
| positive regulation of developmental process |
| nervous system process |
| integral component of plasma membrane |
| regulation of response to stress |
| generation of neurons |
| movement of cell or subcellular component |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of immune system process |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of transport |
| immune response |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Parthenolide 2.5μM R05 exp238 | 2.07 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 1/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6144
- Expression level (log2 read counts): -5.6
Expression Distribution
CCR2 Expression in NALM6 Cells: -5.6
