CCR7
Gene Information
- Official Symbol: CCR7
- Official Name: C-C motif chemokine receptor 7
- Aliases and Previous Symbols: N/A
- Entrez ID: 1236
- UniProt: P32248
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.
Pfam Domains GO Terms
Pfam Domains
| 7tm 1 |
GO Terms
| positive regulation of immunological synapse formation |
| positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation |
| chemokine (C-C motif) ligand 21 binding |
| C-C motif chemokine 21 receptor activity |
| C-C motif chemokine 19 receptor activity |
| chemokine (C-C motif) ligand 19 binding |
| chemokine (C-C motif) ligand 19 signaling pathway |
| lymphocyte migration into lymph node |
| positive regulation of T cell costimulation |
| interleukin-12 secretion |
| regulation of T cell costimulation |
| myeloid dendritic cell chemotaxis |
| regulation of immunological synapse formation |
| regulation of dendritic cell dendrite assembly |
| interleukin-12 production |
| chemokine (C-C motif) ligand 21 signaling pathway |
| lymphocyte migration into lymphoid organs |
| mature conventional dendritic cell differentiation |
| establishment of T cell polarity |
| positive regulation of hypersensitivity |
| positive regulation of dendritic cell antigen processing and presentation |
| establishment of lymphocyte polarity |
| negative regulation of dendritic cell apoptotic process |
| regulation of hypersensitivity |
| positive regulation of acute inflammatory response to antigenic stimulus |
| positive regulation of dendritic cell chemotaxis |
| positive regulation of antigen processing and presentation |
| regulation of dendritic cell chemotaxis |
| regulation of dendritic cell apoptotic process |
| regulation of dendritic cell antigen processing and presentation |
| negative thymic T cell selection |
| negative T cell selection |
| positive regulation of inflammatory response to antigenic stimulus |
| positive regulation of pseudopodium assembly |
| regulation of acute inflammatory response to antigenic stimulus |
| immunological synapse formation |
| regulation of pseudopodium assembly |
| positive regulation of T cell receptor signaling pathway |
| positive regulation of humoral immune response |
| dendritic cell chemotaxis |
| response to nitric oxide |
| thymic T cell selection |
| positive regulation of glycoprotein biosynthetic process |
| regulation of antigen processing and presentation |
| dendritic cell migration |
| positive regulation of glycoprotein metabolic process |
| positive regulation of antigen receptor-mediated signaling pathway |
| response to prostaglandin E |
| C-C chemokine receptor activity |
| positive regulation of neutrophil chemotaxis |
| chemokine binding |
| C-C chemokine binding |
| ruffle organization |
| regulation of inflammatory response to antigenic stimulus |
| positive regulation of granulocyte chemotaxis |
| positive regulation of acute inflammatory response |
| positive regulation of neutrophil migration |
| regulation of neutrophil chemotaxis |
| positive regulation of filopodium assembly |
| response to prostaglandin |
| positive regulation of phosphatidylinositol 3-kinase activity |
| dendritic cell differentiation |
| positive regulation of interleukin-12 production |
| positive regulation of lipid kinase activity |
| regulation of neutrophil migration |
| regulation of T cell receptor signaling pathway |
| T cell selection |
| regulation of glycoprotein biosynthetic process |
| regulation of granulocyte chemotaxis |
| regulation of acute inflammatory response |
| regulation of glycoprotein metabolic process |
| regulation of filopodium assembly |
| negative regulation of leukocyte apoptotic process |
| regulation of interleukin-1 beta secretion |
| T cell differentiation in thymus |
| cytokine secretion |
| positive regulation of phospholipid metabolic process |
| response to bronchodilator |
| positive regulation of cell-matrix adhesion |
| regulation of phosphatidylinositol 3-kinase activity |
| regulation of interleukin-12 production |
| regulation of interleukin-1 secretion |
| release of sequestered calcium ion into cytosol |
| negative regulation of sequestering of calcium ion |
| regulation of antigen receptor-mediated signaling pathway |
| regulation of lipid kinase activity |
| lymphocyte migration |
| calcium ion transmembrane import into cytosol |
| cell-cell recognition |
| calcium ion transport into cytosol |
| chemokine-mediated signaling pathway |
| regulation of interleukin-1 beta production |
| regulation of leukocyte apoptotic process |
| regulation of phospholipid metabolic process |
| response to fatty acid |
| positive regulation of leukocyte chemotaxis |
| cytosolic calcium ion transport |
| response to chemokine |
| cellular response to chemokine |
| positive regulation of actin filament polymerization |
| regulation of interleukin-1 production |
| activation of GTPase activity |
| regulation of interferon-gamma production |
| positive regulation of plasma membrane bounded cell projection assembly |
| myeloid leukocyte differentiation |
| regulation of leukocyte chemotaxis |
| regulation of cell-matrix adhesion |
| establishment of cell polarity |
| positive regulation of cell-substrate adhesion |
| regulation of sequestering of calcium ion |
| myeloid leukocyte migration |
| positive regulation of protein polymerization |
| positive regulation of leukocyte migration |
| T cell differentiation |
| positive regulation of chemotaxis |
| regulation of humoral immune response |
| positive regulation of inflammatory response |
| positive regulation of JNK cascade |
| positive regulation of lipid metabolic process |
| leukocyte chemotaxis |
| calcium-mediated signaling |
| cytokine production |
| protein secretion |
| establishment of protein localization to extracellular region |
| positive regulation of protein kinase B signaling |
| protein localization to extracellular region |
| regulation of actin filament polymerization |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| peptide secretion |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| positive regulation of I-kappaB kinase/NF-kappaB signaling |
| regulation of JNK cascade |
| response to ketone |
| response to reactive oxygen species |
| regulation of leukocyte migration |
| establishment or maintenance of cell polarity |
| positive regulation of supramolecular fiber organization |
| calcium ion transmembrane transport |
| homeostasis of number of cells |
| regulation of plasma membrane bounded cell projection assembly |
| regulation of cell projection assembly |
| positive regulation of T cell activation |
| regulation of cytokine secretion |
| cell chemotaxis |
| positive regulation of ERK1 and ERK2 cascade |
| regulation of cell-substrate adhesion |
| regulation of chemotaxis |
| positive regulation of leukocyte cell-cell adhesion |
| myeloid cell differentiation |
| regulation of protein kinase B signaling |
| positive regulation of cytoskeleton organization |
| regulation of protein polymerization |
| response to alcohol |
| regulation of stress-activated MAPK cascade |
| T cell activation |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| regulation of stress-activated protein kinase signaling cascade |
| lymphocyte differentiation |
| cell recognition |
| positive regulation of protein complex assembly |
| calcium ion transport |
| positive regulation of cell-cell adhesion |
| regulation of actin filament organization |
| positive regulation of cytosolic calcium ion concentration |
| regulation of ERK1 and ERK2 cascade |
| divalent metal ion transport |
| regulation of leukocyte cell-cell adhesion |
| divalent inorganic cation transport |
| response to lipopolysaccharide |
| regulation of T cell activation |
| response to molecule of bacterial origin |
| regulation of cytosolic calcium ion concentration |
| leukocyte differentiation |
| regulation of inflammatory response |
| second-messenger-mediated signaling |
| regulation of actin cytoskeleton organization |
| response to acid chemical |
| regulation of supramolecular fiber organization |
| positive regulation of lymphocyte activation |
| regulation of cellular component size |
| leukocyte migration |
| positive regulation of cell projection organization |
| lymphocyte activation |
| response to oxidative stress |
| regulation of actin filament-based process |
| external side of plasma membrane |
| regulation of lipid metabolic process |
| regulation of cell-cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of cell adhesion |
| positive regulation of GTPase activity |
| positive regulation of cell activation |
| cellular calcium ion homeostasis |
| positive regulation of cytokine production |
| calcium ion homeostasis |
| regulation of protein complex assembly |
| regulation of protein secretion |
| cellular divalent inorganic cation homeostasis |
| positive regulation of defense response |
| regulation of GTPase activity |
| divalent inorganic cation homeostasis |
| regulation of peptide secretion |
| inflammatory response |
| positive regulation of cell migration |
| regulation of lymphocyte activation |
| regulation of anatomical structure size |
| positive regulation of cellular component biogenesis |
| positive regulation of cell motility |
| response to inorganic substance |
| positive regulation of protein kinase activity |
| positive regulation of cellular component movement |
| regulation of cytoskeleton organization |
| positive regulation of MAPK cascade |
| chemotaxis |
| taxis |
| positive regulation of locomotion |
| cellular metal ion homeostasis |
| hemopoiesis |
| inorganic cation transmembrane transport |
| positive regulation of kinase activity |
| regulation of leukocyte activation |
| positive regulation of response to external stimulus |
| hematopoietic or lymphoid organ development |
| cation transmembrane transport |
| cell surface |
| positive regulation of organelle organization |
| metal ion homeostasis |
| cellular cation homeostasis |
| metal ion transport |
| regulation of cell activation |
| cellular ion homeostasis |
| inorganic ion transmembrane transport |
| immune system development |
| positive regulation of transferase activity |
| cytokine-mediated signaling pathway |
| regulation of cell adhesion |
| response to bacterium |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cytokine production |
| cation homeostasis |
| regulation of protein transport |
| regulation of cell projection organization |
| inorganic ion homeostasis |
| G protein-coupled receptor activity |
| regulation of cellular response to stress |
| regulation of peptide transport |
| cellular chemical homeostasis |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| regulation of defense response |
| positive regulation of hydrolase activity |
| ion homeostasis |
| regulation of protein kinase activity |
| regulation of secretion |
| cation transport |
| regulation of cell migration |
| response to lipid |
| positive regulation of immune response |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| cellular homeostasis |
| negative regulation of programmed cell death |
| response to hormone |
| regulation of cell motility |
| leukocyte activation |
| ion transmembrane transport |
| regulation of cellular component biogenesis |
| cell migration |
| regulation of transferase activity |
| regulation of locomotion |
| regulation of cellular component movement |
| negative regulation of cell death |
| secretion by cell |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| response to drug |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| export from cell |
| positive regulation of phosphorylation |
| cell activation |
| localization of cell |
| cell motility |
| response to nitrogen compound |
| regulation of response to external stimulus |
| response to cytokine |
| chemical homeostasis |
| secretion |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of immune response |
| positive regulation of immune system process |
| cell projection organization |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| mitochondrion |
| transmembrane transport |
| regulation of hydrolase activity |
| regulation of organelle organization |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| G protein-coupled receptor signaling pathway |
| response to biotic stimulus |
| defense response |
| ion transport |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| protein transport |
| peptide transport |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| amide transport |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of immune system process |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
| nitrogen compound transport |
| regulation of transport |
| immune response |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| 2-Methoxyestradiol 0.55μM R07 exp310 | 1.74 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RRM1 | 0.712 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10033
- Expression level (log2 read counts): -2.08
Expression Distribution
CCR7 Expression in NALM6 Cells: -2.08
