CCRN4L

Entrez Summary: N/A
UniProt Summary: Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly(A) tails of specific target mRNAs leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by activating PPARG transcriptional activity in a deadenylase- independent manner by facilitating its nuclear translocation. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.05μM R00 exp7	-2.03
YM155 0.0002μM R01 exp61	-1.95
BI-2536 0.001μM R01 exp41	-1.92
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-1.76
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	1.85
Aminopterin 0.005μM R07 exp335	2.3

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

deadenylation-dependent decapping of nuclear-transcribed mRNA
poly(A)-specific ribonuclease activity
cytoplasmic mRNA processing body assembly
CCR4-NOT complex
nuclear-transcribed mRNA poly(A) tail shortening
3-5-exoribonuclease activity
RNA phosphodiester bond hydrolysis, exonucleolytic
negative regulation of osteoblast differentiation
mRNA stabilization
RNA stabilization
negative regulation of mRNA catabolic process
negative regulation of RNA catabolic process
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
positive regulation of fat cell differentiation
circadian regulation of gene expression
negative regulation of ossification
negative regulation of mRNA metabolic process
P-body
regulation of osteoblast differentiation
regulation of circadian rhythm
regulation of fat cell differentiation
regulation of embryonic development
circadian rhythm
RNA phosphodiester bond hydrolysis
mRNA binding
regulation of mRNA stability
regulation of RNA stability
regulation of ossification
nuclear-transcribed mRNA catabolic process
regulation of mRNA catabolic process
mRNA catabolic process
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
RNA catabolic process
negative regulation of cellular catabolic process
rhythmic process
nucleic acid phosphodiester bond hydrolysis
negative regulation of catabolic process
response to lipopolysaccharide
response to molecule of bacterial origin