CCT3

Gene Information

Official Symbol: CCT3
Official Name: chaperonin containing TCP1 subunit 3
Aliases and Previous Symbols: N/A
Entrez ID: 7203
UniProt: P49368
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. {ECO:0000269|PubMed:20080638}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Demecolcine 0.03μM R05 exp228	-2.2
Daidzin 10μM R06 exp280	-2.02
JQ1 0.8μM R08 exp435	-1.91
Arsenate 40μM R06 exp264	-1.77
Vitamin-D3 40μM R08 exp536	-1.75
CCCP 0.1μM R00 exp10	1.87
Rucaparib 6.5μM R08 exp520	1.97

Global Fraction of Cell Lines Where Essential: 739/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 403
Expression level (log2 read counts): 8.95

Expression Distribution

zona pellucida receptor complex
regulation of protein localization to Cajal body
positive regulation of protein localization to Cajal body
positive regulation of establishment of protein localization to telomere
regulation of establishment of protein localization to telomere
chaperonin-containing T-complex
regulation of establishment of protein localization to chromosome
positive regulation of protein localization to chromosome, telomeric region
regulation of protein localization to chromosome, telomeric region
positive regulation of telomerase RNA localization to Cajal body
regulation of telomerase RNA localization to Cajal body
pore complex assembly
positive regulation of telomere maintenance via telomerase
binding of sperm to zona pellucida
positive regulation of telomere maintenance via telomere lengthening
toxin transport
positive regulation of telomere maintenance
sperm-egg recognition
regulation of telomere maintenance via telomerase
regulation of telomere maintenance via telomere lengthening
positive regulation of DNA biosynthetic process
cell-cell recognition
cell body
positive regulation of protein localization to nucleus
regulation of telomere maintenance
regulation of DNA biosynthetic process
regulation of protein localization to nucleus
unfolded protein binding
single fertilization
fertilization
positive regulation of chromosome organization
protein stabilization
positive regulation of DNA metabolic process
protein folding
cell recognition
regulation of protein stability
microtubule
positive regulation of cellular protein localization
regulation of chromosome organization
regulation of DNA metabolic process