CD247

Gene Information

Official Symbol: CD247
Official Name: CD247 molecule
Aliases and Previous Symbols: N/A
Entrez ID: 919
UniProt: P20963
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098, PubMed:7509083). CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme (PubMed:7509083). Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN) (By similarity). {ECO:0000250|UniProtKB:P24161, ECO:0000269|PubMed:16027224, ECO:0000269|PubMed:2470098, ECO:0000269|PubMed:28465009, ECO:0000269|PubMed:7509083}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12435
Expression level (log2 read counts): -2.14

Expression Distribution

Screen	Score
Vincristine 0.0005μM R04 exp190	-1.71
CCCP 0.1μM R00 exp10	1.76

TCR zetazeta
ITAM

alpha-beta T cell receptor complex
interleukin-2 production
positive regulation of protein localization to cell surface
protein tyrosine kinase binding
regulation of defense response to virus by virus
protein homotrimerization
regulation of protein localization to cell surface
protein trimerization
protein homotetramerization
T cell receptor complex
Fc-gamma receptor signaling pathway involved in phagocytosis
immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
transmembrane signaling receptor activity
Fc receptor mediated stimulatory signaling pathway
Fc-gamma receptor signaling pathway
protein tetramerization
cytokine production
T cell receptor signaling pathway
Fc receptor signaling pathway
antigen receptor-mediated signaling pathway
positive regulation of cellular protein localization
phagocytosis
protein homooligomerization
immune response-activating cell surface receptor signaling pathway
immune response-regulating cell surface receptor signaling pathway
protein complex oligomerization
regulation of cellular protein localization
immune response-activating signal transduction
immune response-regulating signaling pathway
adaptive immune response
activation of immune response
viral process
symbiotic process
interspecies interaction between organisms
positive regulation of immune response
protein homodimerization activity
regulation of cellular localization
regulation of protein localization
identical protein binding
immune effector process