CD55

Gene Information

Official Symbol: CD55
Official Name: CD55 molecule (Cromer blood group)
Aliases and Previous Symbols: N/A
Entrez ID: 1604
UniProt: P08174
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins. [provided by RefSeq, Jul 2014]. Sequence Note: This RefSeq record represents the CD55*001.1.1 allele.
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16968
Expression level (log2 read counts): 5.23

Expression Distribution

positive regulation of CD4-positive, alpha-beta T cell proliferation
CD4-positive, alpha-beta T cell cytokine production
negative regulation of complement activation
T cell cytokine production
regulation of complement-dependent cytotoxicity
regulation of CD4-positive, alpha-beta T cell proliferation
negative regulation of humoral immune response
positive regulation of alpha-beta T cell proliferation
respiratory burst
cytokine production involved in immune response
regulation of lipopolysaccharide-mediated signaling pathway
regulation of alpha-beta T cell proliferation
positive regulation of CD4-positive, alpha-beta T cell activation
T cell mediated immunity
positive regulation of alpha-beta T cell activation
regulation of CD4-positive, alpha-beta T cell activation
ficolin-1-rich granule membrane
endoplasmic reticulum-Golgi intermediate compartment membrane
virus receptor activity
transport vesicle
regulation of alpha-beta T cell activation
viral entry into host cell
positive regulation of T cell proliferation
secretory granule membrane
regulation of cell killing
anchored component of membrane
entry into host
entry into host cell
regulation of complement activation
negative regulation of immune effector process
positive regulation of lymphocyte proliferation
positive regulation of mononuclear cell proliferation
regulation of humoral immune response
positive regulation of leukocyte proliferation
negative regulation of immune response
cytokine production
lipid binding
regulation of T cell proliferation
interaction with host
complement activation, classical pathway