CDC14A

Entrez Summary: The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
SB203580 25μM R03 exp149	-1.9
Apcin 25μM plus proTAME 2μM R04 exp177	2.39

kinociliary basal body
kinocilium
mitotic cell cycle arrest
stereocilium tip
regulation of exit from mitosis
positive regulation of cytokinesis
protein tyrosine/serine/threonine phosphatase activity
protein serine/threonine phosphatase activity
mitotic spindle
positive regulation of cell division
regulation of cytokinesis
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
spindle pole
sensory perception of sound
cell cycle arrest
sensory perception of mechanical stimulus
regulation of cell division
regulation of mitotic nuclear division
regulation of nuclear division
protein dephosphorylation
nuclear body
positive regulation of cell cycle process
negative regulation of mitotic cell cycle
dephosphorylation
cilium assembly
cilium organization
positive regulation of cell cycle
regulation of mitotic cell cycle phase transition
plasma membrane bounded cell projection assembly
regulation of cell cycle phase transition
cell projection assembly
microtubule cytoskeleton organization
centrosome
cell division
negative regulation of cell cycle
regulation of mitotic cell cycle
microtubule-based process
mitotic cell cycle
regulation of cell cycle process