CDC25B

Entrez Summary: CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008]. COMPLETENESS: complete on the 3' end.
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nutlin-3A 1.6μM R06 exp294	-2.12
5-Fluorouracil 20μM R00 exp2	-1.94
Cidofovir 10μM R07 exp345	-1.92
Sulforaphane 9μM R08 exp526 no dilution day6	-1.85
Vinblastine 0.002μM R01 exp60	-1.77
VHL-ligand-1 20μM R07 exp421	-1.71
Calcium Ionophore 0.4μM R07 exp342	1.71
GSK626616 14μM R08 exp485	1.74

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Rhodanese
M-inducer phosp

positive regulation of G2/MI transition of meiotic cell cycle
regulation of G2/MI transition of meiotic cell cycle
positive regulation of meiotic cell cycle phase transition
female meiosis I
regulation of meiotic cell cycle phase transition
oocyte maturation
positive regulation of meiotic cell cycle
positive regulation of G2/M transition of mitotic cell cycle
positive regulation of cell cycle G2/M phase transition
female meiotic nuclear division
oocyte development
positive regulation of cytokinesis
phosphoprotein phosphatase activity
oocyte differentiation
regulation of meiotic cell cycle
positive regulation of mitotic cell cycle phase transition
positive regulation of reproductive process
oogenesis
positive regulation of cell division
regulation of cytokinesis
positive regulation of cell cycle phase transition
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
meiosis I
meiosis I cell cycle process
spindle pole
female gamete generation
G2/M transition of mitotic cell cycle
cell cycle G2/M phase transition
anatomical structure maturation
positive regulation of mitotic cell cycle
meiotic nuclear division
cell maturation
regulation of reproductive process
meiotic cell cycle process
regulation of cell division
regulation of G2/M transition of mitotic cell cycle
regulation of cell cycle G2/M phase transition
protein dephosphorylation
meiotic cell cycle