CDH11

Entrez Summary: This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. [provided by RefSeq, Jul 2008].
UniProt Summary: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Cadherin C
Cadherin

corticospinal tract morphogenesis
central nervous system projection neuron axonogenesis
cell-cell adhesion mediated by cadherin
catenin complex
central nervous system neuron axonogenesis
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cytoskeletal protein binding
central nervous system neuron development
Schaffer collateral - CA1 synapse
adherens junction organization
cell-cell junction assembly
cell-cell adherens junction
cell-cell junction organization
cell junction assembly
homophilic cell adhesion via plasma membrane adhesion molecules
central nervous system neuron differentiation
cell junction organization
cell-cell adhesion via plasma-membrane adhesion molecules
ossification
cadherin binding
glutamatergic synapse
axonogenesis
axon development
cell morphogenesis involved in neuron differentiation
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
skeletal system development
cell-cell adhesion
cell part morphogenesis
cell morphogenesis involved in differentiation
cell surface
neuron projection development
calcium ion binding
cell morphogenesis
neuron development
cellular component morphogenesis
protein homodimerization activity