CDK16

Entrez Summary: The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009].
UniProt Summary: Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser- 336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Pkinase
Pkinase Tyr

growth hormone secretion
cyclin-dependent protein serine/threonine kinase activity
regulation of insulin secretion involved in cellular response to glucose stimulus
peptide hormone secretion
extrinsic component of cytoplasmic side of plasma membrane
hormone secretion
hormone transport
synaptic vesicle
microtubule cytoskeleton
signal release
peptide secretion
regulation of insulin secretion
regulation of peptide hormone secretion
regulation of hormone secretion
neuron projection
protein serine/threonine kinase activity
regulation of protein secretion
regulation of peptide secretion
regulation of hormone levels
spermatogenesis
cell junction
male gamete generation
neuron projection development
gamete generation
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
regulation of secretion by cell
exocytosis
regulation of secretion
neuron development
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
regulation of cellular localization
protein phosphorylation
multi-organism reproductive process
secretion by cell
neuron differentiation
regulation of protein localization