CDX2
Gene Information
- Official Symbol: CDX2
- Official Name: caudal type homeobox 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 1045
- UniProt: Q99626
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.
Pfam Domains GO Terms
Pfam Domains
| Caudal act |
| Homeobox |
GO Terms
| regulation of somitogenesis |
| trophectodermal cell differentiation |
| intestinal epithelial cell differentiation |
| methyl-CpG binding |
| condensed nuclear chromosome |
| blastocyst formation |
| establishment or maintenance of epithelial cell apical/basal polarity |
| labyrinthine layer development |
| establishment or maintenance of bipolar cell polarity |
| establishment or maintenance of apical/basal cell polarity |
| anterior/posterior axis specification |
| endosome to lysosome transport |
| transcriptional repressor complex |
| somatic stem cell population maintenance |
| axis specification |
| embryonic placenta development |
| columnar/cuboidal epithelial cell differentiation |
| blastocyst development |
| RNA polymerase II distal enhancer sequence-specific DNA binding |
| lysosomal transport |
| regulation of embryonic development |
| digestive tract development |
| stem cell population maintenance |
| maintenance of cell number |
| vacuolar transport |
| digestive system development |
| placenta development |
| establishment or maintenance of cell polarity |
| anterior/posterior pattern specification |
| transcription corepressor activity |
| DNA-binding transcription repressor activity, RNA polymerase II-specific |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| regionalization |
| in utero embryonic development |
| reproductive structure development |
| reproductive system development |
| embryonic organ development |
| pattern specification process |
| transcription by RNA polymerase II |
| blood vessel development |
| vasculature development |
| cardiovascular system development |
| chordate embryonic development |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| embryo development ending in birth or egg hatching |
| RNA biosynthetic process |
| developmental process involved in reproduction |
| DNA-binding transcription factor activity |
| epithelial cell differentiation |
| tube development |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| positive regulation of cell population proliferation |
| animal organ morphogenesis |
| positive regulation of cell differentiation |
| embryo development |
| regulation of anatomical structure morphogenesis |
| nucleobase-containing compound biosynthetic process |
| epithelium development |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of transcription, DNA-templated |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| organic cyclic compound biosynthetic process |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| intracellular transport |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of cell population proliferation |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| tissue development |
| macromolecule biosynthetic process |
| regulation of cell differentiation |
| establishment of localization in cell |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| vesicle-mediated transport |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| FK-506 5μM R07 exp358 | -1.85 |
| GW501516 25μM R06 exp285 | -1.85 |
| Cyclosporin-A 0.8μM R07 exp347 | -1.7 |
| Cadmium 60μM R08 exp462 | 1.98 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 2/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13864
- Expression level (log2 read counts): -3.9
Expression Distribution
CDX2 Expression in NALM6 Cells: -3.9
