CEP89

Entrez Summary: N/A
UniProt Summary: Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity. {ECO:0000269|PubMed:23348840, ECO:0000269|PubMed:23575228}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Isonicotinamide 500μM R03 exp129	-1.7
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.77
WYE-354 6μM R02 exp90	1.93
Nifuroxazide 1μM R01 exp51	2.02
Lapatinib 5μM R01 exp47	2.32

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ciliary transition fiber
non-motile cilium
non-motile cilium assembly
mitochondrial intermembrane space
ciliary basal body-plasma membrane docking
motile cilium
spindle pole
centriole
organelle localization by membrane tethering
membrane docking
cilium assembly
cilium organization
anterograde trans-synaptic signaling
chemical synaptic transmission
trans-synaptic signaling
mitochondrion organization
plasma membrane bounded cell projection assembly
cell projection assembly
synaptic signaling
centrosome
organelle localization
organelle assembly
cell-cell signaling
plasma membrane bounded cell projection organization
cell projection organization