CEP97

Entrez Summary: N/A
UniProt Summary: Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome. {ECO:0000269|PubMed:17719545}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of cilium assembly
regulation of mitotic spindle assembly
negative regulation of plasma membrane bounded cell projection assembly
regulation of spindle assembly
negative regulation of organelle assembly
regulation of mitotic spindle organization
regulation of spindle organization
regulation of cilium assembly
ciliary basal body-plasma membrane docking
microtubule organizing center
regulation of mitotic nuclear division
organelle localization by membrane tethering
membrane docking
negative regulation of cell projection organization
regulation of microtubule cytoskeleton organization
regulation of nuclear division
regulation of plasma membrane bounded cell projection assembly
calmodulin binding
regulation of cell projection assembly
regulation of organelle assembly
regulation of microtubule-based process
cilium assembly
cilium organization
negative regulation of organelle organization
plasma membrane bounded cell projection assembly
cell projection assembly
centrosome
regulation of cytoskeleton organization
organelle localization
protein-containing complex
regulation of mitotic cell cycle
regulation of plasma membrane bounded cell projection organization
negative regulation of cellular component organization
regulation of cell projection organization
regulation of cell cycle process
organelle assembly
regulation of cellular component biogenesis
plasma membrane bounded cell projection organization
cell projection organization
regulation of cell cycle