CHAMP1

Entrez Summary: This gene encodes a zinc finger protein that functions as a regulator of chromosome segregation in mitosis. The encoded protein is required for correct alignment of chromosomes on the metaphase plate, and plays a role in maintaining the attachment of sister kinetochores to microtubules from opposite spindle poles. Mutations in this gene are associated with an autosomal dominant form of intellectual disability. [provided by RefSeq, Jul 2017].
UniProt Summary: Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
QNZ 0.01μM R08 exp439	-1.8
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	2.3

sister chromatid biorientation
protein localization to microtubule
attachment of mitotic spindle microtubules to kinetochore
protein localization to kinetochore
protein localization to chromosome, centromeric region
attachment of spindle microtubules to kinetochore
condensed chromosome
Flemming body
protein localization to microtubule cytoskeleton
protein localization to cytoskeleton
mitotic metaphase plate congression
metaphase plate congression
protein localization to chromosome
establishment of chromosome localization
chromosome localization
condensed chromosome kinetochore
mitotic sister chromatid segregation
spindle
sister chromatid segregation
mitotic nuclear division
nucleic acid binding
nuclear chromosome segregation
chromosome segregation
nuclear division
organelle fission
establishment of organelle localization
organelle localization
mitotic cell cycle process
mitotic cell cycle
protein localization to organelle
cell cycle process
chromosome organization
cell cycle
cellular protein localization
cellular macromolecule localization
establishment of localization in cell