CHD6

Entrez Summary: This gene encodes a member of the SNF2/RAD54 helicase protein family. The encoded protein contains two chromodomains, a helicase domain, and an ATPase domain. Several multi-subunit protein complexes remodel chromatin to allow patterns of cell type-specific gene expression, and the encoded protein is thought to be a core member of one or more of these chromatin remodeling complexes. The encoded protein may function as a transcriptional repressor and is involved in the cellular repression of influenza virus replication. [provided by RefSeq, Jul 2013].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
transcription cofactor binding
regulation of transcription from RNA polymerase II promoter in response to oxidative stress
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
positive regulation of transcription from RNA polymerase II promoter in response to stress
DNA-dependent ATPase activity
DNA helicase activity
DNA duplex unwinding
regulation of transcription from RNA polymerase II promoter in response to stress
DNA geometric change
regulation of DNA-templated transcription in response to stress
cellular response to oxidative stress
DNA conformation change
response to oxidative stress
chromatin organization
viral process
symbiotic process
interspecies interaction between organisms
chromosome organization
positive regulation of transcription by RNA polymerase II
DNA binding
ATP binding
positive regulation of transcription, DNA-templated
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
cellular response to stress
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process