CHMP4A

Gene Information

Official Symbol: CHMP4A
Official Name: charged multivesicular body protein 4A
Aliases and Previous Symbols: N/A
Entrez ID: 29082
UniProt: Q9BY43
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:12860994, ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:14583093, ECO:0000269|PubMed:18209100, ECO:0000269|PubMed:22660413}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4046
Expression level (log2 read counts): 4.84

Expression Distribution

Screen	Score
Rapamycin 10μM R00 exp30	-1.97
B02 10μM R08 exp453	1.75

membrane coat
ESCRT III complex
posttranslational protein targeting to endoplasmic reticulum membrane
negative regulation of autophagosome assembly
plasma membrane tubulation
midbody abscission
viral budding via host ESCRT complex
mitotic cytokinetic process
viral budding
multivesicular body assembly
multivesicular body organization
negative regulation of macroautophagy
regulation of autophagosome assembly
cytokinetic process
virion assembly
negative regulation of organelle assembly
regulation of vacuole organization
mitotic metaphase plate congression
cytoplasmic side of plasma membrane
metaphase plate congression
mitotic cytokinesis
establishment of chromosome localization
chromosome localization
endosome organization
ATPase binding
negative regulation of autophagy
protein polymerization
plasma membrane organization
vesicle budding from membrane
cytoskeleton-dependent cytokinesis
cytokinesis
mitotic sister chromatid segregation
protein targeting to ER
establishment of protein localization to endoplasmic reticulum
late endosome membrane
nucleus organization
protein localization to endoplasmic reticulum
sister chromatid segregation
vacuolar transport
cytoplasmic vesicle membrane