CHP1

Gene Information

Official Symbol: CHP1
Official Name: calcineurin like EF-hand protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 11261
UniProt: Q99653
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate- phosphorylations in a calcium-dependent manner. {ECO:0000269|PubMed:10593895, ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:8901634}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UNC1999 2μM R03 exp155	-2.06
Celastrol 0.12μM R05 exp225	-2.01
Nifuroxazide 5μM R03 exp102	-1.98
UM0011500 10μM R05 exp246	-1.83
CCT251545 20μM R07 exp326	-1.82
CR131-b 0.005μM R08 exp474	1.72
Doxorubicin 0.02μM R08 exp478	1.84
42°C R08 exp539	1.89
BI-D1870 2μM R04 exp162	1.89
Docosahexaenoic-acid 50μM R07 exp356	1.98
Q15 1 to 2μM on day4 R04 exp164	2.68
Vemurafenib 6.6μM R02 exp89	3.25
Vemurafenib 6.6μM R08 exp434	3.8
Q15 2.7μM R02 exp79	5.29

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9990
Expression level (log2 read counts): 6.08

Expression Distribution

positive regulation of sodium:proton antiporter activity
regulation of sodium:proton antiporter activity
positive regulation of protein glycosylation
cellular response to acidic pH
negative regulation of protein import into nucleus
negative regulation of protein import
negative regulation of protein autophosphorylation
negative regulation of calcineurin-mediated signaling
regulation of protein glycosylation
negative regulation of calcineurin-NFAT signaling cascade
positive regulation of sodium ion transmembrane transporter activity
hyaluronan catabolic process
positive regulation of glycoprotein biosynthetic process
negative regulation of nucleocytoplasmic transport
positive regulation of sodium ion transmembrane transport
positive regulation of glycoprotein metabolic process
regulation of proton transport
cellular response to pH
response to acidic pH
protein kinase inhibitor activity
negative regulation of protein localization to nucleus
negative regulation of calcium-mediated signaling
positive regulation of protein targeting to membrane
hyaluronan metabolic process
regulation of calcineurin-mediated signaling
regulation of calcineurin-NFAT signaling cascade
positive regulation of sodium ion transport
regulation of protein targeting to membrane
potassium channel regulator activity
response to pH
regulation of glycoprotein biosynthetic process
calcium-ion regulated exocytosis
negative regulation of intracellular protein transport
regulation of glycoprotein metabolic process
regulation of protein autophosphorylation
regulation of sodium ion transmembrane transporter activity
cytoplasmic microtubule organization
regulation of protein import into nucleus
regulation of protein import
negative regulation of intracellular transport