CHRNA1

Entrez Summary: The muscle acetylcholine receptor consiststs of 5 subunits of 4 different types: 2 alpha subunits and 1 each of the beta, gamma, and delta subunits. This gene encodes an alpha subunit that plays a role in acetlycholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Nov 2012].
UniProt Summary: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. {ECO:0000269|PubMed:27375219}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Neur chan memb
Neur chan LBD

skeletal muscle tissue growth
acetylcholine receptor activity
acetylcholine-gated cation-selective channel activity
acetylcholine binding
acetylcholine-gated channel complex
muscle cell cellular homeostasis
ion channel activity
integral component of postsynaptic specialization membrane
synaptic transmission, cholinergic
neuronal action potential
skeletal muscle contraction
neuromuscular synaptic transmission
neuron cellular homeostasis
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
neuromuscular junction development
multicellular organismal movement
musculoskeletal movement
extracellular ligand-gated ion channel activity
response to nicotine
transmission of nerve impulse
excitatory postsynaptic potential
chemical synaptic transmission, postsynaptic
neuromuscular junction
action potential
regulation of postsynaptic membrane potential
neuromuscular process
striated muscle contraction
skeletal muscle tissue development
skeletal muscle organ development
multicellular organismal signaling
postsynaptic membrane
muscle contraction
synapse
synapse organization
striated muscle tissue development
muscle organ development
muscle tissue development
muscle system process
neuron projection
anatomical structure homeostasis