CHTF8

Entrez Summary: N/A
UniProt Summary: Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single- stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression. {ECO:0000269|PubMed:12930902, ECO:0000269|PubMed:17545166}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 85/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	5/28
blood	0/28
bone	5/26
breast	7/33
central nervous system	10/56
cervix	0/4
colorectal	2/17
esophagus	1/13
fibroblast	1/1
gastric	5/16
kidney	5/21
liver	0/20
lung	9/75
lymphocyte	0/16
ovary	4/26
pancreas	1/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	3/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	4/29
uterus	0/5

Expression Distribution

regulation of DNA-directed DNA polymerase activity
positive regulation of DNA-directed DNA polymerase activity
Ctf18 RFC-like complex
DNA clamp loader activity
mitotic sister chromatid cohesion
single-stranded DNA helicase activity
sister chromatid cohesion
regulation of DNA-dependent DNA replication
positive regulation of DNA biosynthetic process
mitotic sister chromatid segregation
regulation of DNA replication
DNA duplex unwinding
regulation of DNA biosynthetic process
DNA geometric change
sister chromatid segregation
mitotic nuclear division
positive regulation of DNA metabolic process
DNA replication
nuclear chromosome segregation
chromosome segregation
nuclear division
DNA conformation change
organelle fission
regulation of DNA metabolic process
mitotic cell cycle process
positive regulation of transferase activity
mitotic cell cycle
regulation of transferase activity
cell cycle process
chromosome organization
cell cycle
positive regulation of catalytic activity
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
positive regulation of molecular function
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of biosynthetic process