CIAPIN1

Entrez Summary: N/A
UniProt Summary: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 (PubMed:23596212). NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). {ECO:0000250|UniProtKB:P36152, ECO:0000250|UniProtKB:Q8WTY4, ECO:0000255|HAMAP-Rule:MF_03115, ECO:0000269|PubMed:23596212}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 524/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	19/28
blood	25/28
bone	21/26
breast	23/33
central nervous system	43/56
cervix	3/4
colorectal	10/17
esophagus	7/13
fibroblast	1/1
gastric	10/16
kidney	16/21
liver	15/20
lung	47/75
lymphocyte	12/16
ovary	21/26
pancreas	12/24
peripheral nervous system	12/16
plasma cell	10/15
prostate	0/1
skin	19/24
soft tissue	6/9
thyroid	1/2
upper aerodigestive	15/22
urinary tract	21/29
uterus	3/5

Expression Distribution

Screen	Score
2-Methoxyestradiol 0.2μM R01 exp40	1.73
YM155 0.0002μM R01 exp61	1.76
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	2.02

iron-sulfur cluster assembly
metallo-sulfur cluster assembly
2 iron, 2 sulfur cluster binding
4 iron, 4 sulfur cluster binding
methyltransferase activity
electron transfer activity
mitochondrial intermembrane space
electron transport chain
cofactor biosynthetic process
methylation
sulfur compound metabolic process
generation of precursor metabolites and energy
cofactor metabolic process
hemopoiesis
hematopoietic or lymphoid organ development
immune system development
nucleolus
negative regulation of apoptotic process
negative regulation of programmed cell death
apoptotic process
oxidation-reduction process
negative regulation of cell death
programmed cell death
cell death
mitochondrion
regulation of apoptotic process
regulation of programmed cell death
regulation of cell death