CITED2

Gene Information

Official Symbol: CITED2
Official Name: Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2
Aliases and Previous Symbols: N/A
Entrez ID: 10370
UniProt: Q99967
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene inhibits transactivation of HIF1A-induced genes by competing with binding of hypoxia-inducible factor 1-alpha to p300-CH1. Mutations in this gene are a cause of cardiac septal defects. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].
UniProt Summary: Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator- activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left- right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region. {ECO:0000269|PubMed:11581164, ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:15051727}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rifampicin 10μM R00 exp32	-1.83
Cycloheximide 0.2μM R00 exp15	-1.81
TRAIL 50ng/ml R00 exp36	1.72
UMK57 1μM R01 exp59	1.73
Lapatinib 5μM R01 exp47	1.81
39°C R06 exp303	2.22
Bisphenol S 100μM R08 exp458	2.3
Q15 1 to 2μM on day4 R04 exp164	2.34

Global Fraction of Cell Lines Where Essential: 2/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10572
Expression level (log2 read counts): 3.58

Expression Distribution

adrenal cortex formation
adrenal cortex development
nodal signaling pathway involved in determination of left/right asymmetry
nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
regulation of transcription from RNA polymerase II promoter involved in determination of left/right symmetry
embryonic heart tube left/right pattern formation
negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
determination of left/right asymmetry in lateral mesoderm
LBD domain binding
positive regulation of male gonad development
regulation of male gonad development
positive regulation of peroxisome proliferator activated receptor signaling pathway
positive regulation of gonad development
nodal signaling pathway
negative regulation of transcription from RNA polymerase II promoter in response to stress
lateral mesoderm development
left/right axis specification
regulation of peroxisome proliferator activated receptor signaling pathway
regulation of gonad development
left/right pattern formation
sex determination
activin receptor signaling pathway
adrenal gland development
positive regulation of cellular response to transforming growth factor beta stimulus
positive regulation of transforming growth factor beta receptor signaling pathway
histone acetyltransferase binding
spleen development
response to fluid shear stress
regulation of animal organ formation
ventricular septum morphogenesis
ventricular septum development
cardiac septum morphogenesis
outflow tract morphogenesis
response to estrogen
embryonic heart tube development
regulation of transcription from RNA polymerase II promoter in response to hypoxia
positive regulation of reproductive process
axis specification
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
cardiac septum development