CKS2

Entrez Summary: N/A
UniProt Summary: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Apcin 50 to 100μM on day4 R04 exp176	-2.2
Ethanol 0.01 R05 exp234	1.75
Temozolomide 200μM R04 exp189	1.77
Cerivastatin 0.15μM R05 exp226	1.81
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	1.94
BI-D1870 2μM R04 exp162	2.02
Nutlin-3A 1.6μM R06 exp294	3.37
Etoposide 0.1μM R05 exp198	3.61

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cyclin-dependent protein serine/threonine kinase activator activity
cyclin-dependent protein kinase holoenzyme complex
positive regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of cyclin-dependent protein kinase activity
SCF ubiquitin ligase complex
ubiquitin binding
regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of cyclin-dependent protein kinase activity
meiosis I
meiosis I cell cycle process
histone binding
meiotic nuclear division
meiotic cell cycle process
meiotic cell cycle
mitotic cell cycle phase transition
cell cycle phase transition
nuclear division
organelle fission
positive regulation of protein serine/threonine kinase activity
positive regulation of cell cycle
chromatin binding
protein kinase binding
cell division
regulation of protein serine/threonine kinase activity
positive regulation of protein kinase activity
cell population proliferation
positive regulation of kinase activity
mitotic cell cycle process
regulation of mitotic cell cycle
positive regulation of transferase activity
mitotic cell cycle
regulation of protein kinase activity
regulation of kinase activity
regulation of transferase activity
cell cycle process
positive regulation of protein phosphorylation
positive regulation of phosphorylation
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
regulation of cell cycle