CLEC4A

Gene Information

Official Symbol: CLEC4A
Official Name: C-type lectin domain family 4 member A
Aliases and Previous Symbols: N/A
Entrez ID: 50856
UniProt: Q9UMR7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. {ECO:0000269|PubMed:10438934}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14438
Expression level (log2 read counts): -0.46

Expression Distribution

dendritic cell antigen processing and presentation
plasmacytoid dendritic cell antigen processing and presentation
CD8-positive, alpha-beta T cell activation
mannose binding
negative regulation of tumor necrosis factor production
alpha-beta T cell activation
negative regulation of tumor necrosis factor superfamily cytokine production
antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of peptide antigen via MHC class I
stimulatory C-type lectin receptor signaling pathway
innate immune response activating cell surface receptor signaling pathway
transmembrane signaling receptor activity
regulation of tumor necrosis factor production
regulation of tumor necrosis factor superfamily cytokine production
carbohydrate binding
antigen processing and presentation of exogenous peptide antigen
antigen processing and presentation of exogenous antigen
antigen processing and presentation of peptide antigen
antigen processing and presentation
innate immune response-activating signal transduction
T cell activation
activation of innate immune response
negative regulation of cytokine production
positive regulation of innate immune response
positive regulation of response to biotic stimulus
lymphocyte activation
immune response-activating cell surface receptor signaling pathway
regulation of innate immune response
positive regulation of defense response
immune response-regulating cell surface receptor signaling pathway
positive regulation of multi-organism process
regulation of response to biotic stimulus
immune response-activating signal transduction
immune response-regulating signaling pathway
positive regulation of response to external stimulus
adaptive immune response
activation of immune response
regulation of cytokine production
calcium ion binding
regulation of defense response