CLECL1

Entrez Summary: N/A
UniProt Summary: May function in mediating immune cell-cell interactions. May act as a T-cell costimulatory molecule, enhancing anti-CD3- induced proliferation. May play a role in the interaction of dendritic cells with T-cells and the cells of the adaptive immune response. {ECO:0000269|PubMed:12421943}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Alpha-Amanitin 0.5μM R00 exp5	-1.91
PT-1 25μM R07 exp392	1.9

B cell adhesion
interleukin-4 secretion
interleukin-4 production
cytokine secretion
leukocyte cell-cell adhesion
positive regulation of T cell proliferation
positive regulation of lymphocyte proliferation
positive regulation of mononuclear cell proliferation
positive regulation of leukocyte proliferation
cytokine production
regulation of T cell proliferation
protein secretion
establishment of protein localization to extracellular region
protein localization to extracellular region
peptide secretion
carbohydrate binding
positive regulation of T cell activation
regulation of lymphocyte proliferation
regulation of mononuclear cell proliferation
positive regulation of leukocyte cell-cell adhesion
regulation of leukocyte proliferation
positive regulation of cell-cell adhesion
regulation of leukocyte cell-cell adhesion
regulation of T cell activation
positive regulation of lymphocyte activation
regulation of cell-cell adhesion
positive regulation of leukocyte activation
positive regulation of cell adhesion
positive regulation of cell activation
cell-cell adhesion
regulation of lymphocyte activation
regulation of leukocyte activation
regulation of cell activation
regulation of cell adhesion
molecular function
positive regulation of cell population proliferation
cell adhesion
biological adhesion
secretion by cell
export from cell