CLGN

Entrez Summary: N/A
UniProt Summary: Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein folding chaperone
binding of sperm to zona pellucida
sperm-egg recognition
cell-cell recognition
endoplasmic reticulum unfolded protein response
cellular response to unfolded protein
unfolded protein binding
single fertilization
cellular response to topologically incorrect protein
response to unfolded protein
fertilization
nuclear envelope
response to topologically incorrect protein
protein folding
cell recognition
response to endoplasmic reticulum stress
calcium ion binding
sexual reproduction
endoplasmic reticulum membrane
multi-organism reproductive process
endoplasmic reticulum
reproductive process
reproduction
protein-containing complex assembly
cellular response to stress
protein-containing complex subunit organization