CNGA1

Entrez Summary: The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008].
UniProt Summary: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cNMP binding
Ion trans

intracellular cGMP-activated cation channel activity
intracellular cAMP-activated cation channel activity
rhodopsin mediated signaling pathway
cGMP binding
photoreceptor outer segment membrane
phototransduction, visible light
regulation of rhodopsin mediated signaling pathway
phototransduction
detection of visible light
detection of light stimulus
cellular response to light stimulus
detection of external stimulus
detection of abiotic stimulus
regulation of G protein-coupled receptor signaling pathway
cellular response to radiation
visual perception
sensory perception of light stimulus
response to light stimulus
cellular response to environmental stimulus
cellular response to abiotic stimulus
response to radiation
cation transmembrane transport
detection of stimulus
cation transport
ion transmembrane transport
sensory perception
regulation of response to external stimulus
response to abiotic stimulus
transmembrane transport
G protein-coupled receptor signaling pathway
ion transport
nervous system process
integral component of plasma membrane
system process