CNIH2

Gene Information

Official Symbol: CNIH2
Official Name: cornichon family AMPA receptor auxiliary protein 2
Aliases and Previous Symbols: N/A
Entrez ID: 254263
UniProt: Q6PI25
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors. {ECO:0000269|PubMed:20805473}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9554
Expression level (log2 read counts): -1.65

Expression Distribution

Screen	Score
MKC9989 10μM R03 exp133	-2.11
CB-5083 0.4μM R08 exp468	-1.85
UM0011500 5μM R05 exp245	-1.83

negative regulation of synaptic vesicle transport
negative regulation of vesicle transport along microtubule
negative regulation of anterograde synaptic vesicle transport
negative regulation of receptor localization to synapse
regulation of anterograde synaptic vesicle transport
regulation of vesicle transport along microtubule
regulation of synaptic vesicle transport
regulation of organelle transport along microtubule
regulation of postsynaptic neurotransmitter receptor activity
regulation of receptor localization to synapse
regulation of AMPA receptor activity
regulation of protein localization to synapse
AMPA glutamate receptor complex
synaptic transmission, glutamatergic
regulation of microtubule-based movement
dendritic shaft
regulation of NMDA receptor activity
integral component of postsynaptic density membrane
ER to Golgi transport vesicle membrane
negative regulation of intracellular transport
vesicle targeting, rough ER to cis-Golgi
COPII vesicle coating
regulation of glutamate receptor signaling pathway
vesicle coating
COPII-coated vesicle budding
vesicle targeting, to, from or within Golgi
endoplasmic reticulum-Golgi intermediate compartment membrane
regulation of neurotransmitter receptor activity
Golgi vesicle budding
localization within membrane
vesicle targeting
vesicle budding from membrane
regulation of nervous system process
dendritic spine
regulation of cation channel activity
regulation of signaling receptor activity
establishment of vesicle localization
vesicle localization
postsynaptic membrane
endoplasmic reticulum to Golgi vesicle-mediated transport