CNIH3

Entrez Summary: N/A
UniProt Summary: Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. {ECO:0000269|PubMed:20805473}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Taxol 0.004μM R03 exp103	1.7
Thapsigargin 0.005μM R07 exp407	1.8

channel regulator activity
regulation of AMPA receptor activity
AMPA glutamate receptor complex
synaptic transmission, glutamatergic
dendritic shaft
ER to Golgi transport vesicle membrane
COPII vesicle coating
vesicle targeting, rough ER to cis-Golgi
regulation of glutamate receptor signaling pathway
vesicle coating
COPII-coated vesicle budding
endoplasmic reticulum-Golgi intermediate compartment membrane
vesicle targeting, to, from or within Golgi
regulation of neurotransmitter receptor activity
Golgi vesicle budding
vesicle targeting
vesicle budding from membrane
regulation of cation channel activity
regulation of signaling receptor activity
establishment of vesicle localization
vesicle localization
postsynaptic membrane
endoplasmic reticulum to Golgi vesicle-mediated transport
regulation of ion transmembrane transporter activity
regulation of transmembrane transporter activity
regulation of transporter activity
vesicle organization
regulation of cation transmembrane transport
establishment of organelle localization
Golgi vesicle transport
chemical synaptic transmission
anterograde trans-synaptic signaling
regulation of membrane potential
trans-synaptic signaling
synaptic signaling
regulation of ion transmembrane transport
cell junction
regulation of transmembrane transport
organelle localization
Golgi membrane