CNN1

Entrez Summary: N/A
UniProt Summary: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
TGF-beta1 44ng/ml R08 exp528	-2.07
Bisphenol A 100μM R06 exp269	-1.89
NFN1 0.1μM R01 exp49	-1.79
UM0011500 5μM R05 exp245	-1.78
Ammonium tetrathiomolybdate 10μM R08 exp448	-1.76
UMK57 0.6μM R03 exp107	2.25

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

CH
Calponin

negative regulation of vascular smooth muscle cell proliferation
negative regulation of smooth muscle cell proliferation
regulation of vascular smooth muscle cell proliferation
regulation of smooth muscle contraction
actomyosin structure organization
regulation of smooth muscle cell proliferation
regulation of muscle contraction
calmodulin binding
regulation of muscle system process
actin binding
cytoskeleton
focal adhesion
actin cytoskeleton organization
actin filament-based process
regulation of system process
negative regulation of cell population proliferation
cytoskeleton organization
regulation of cell population proliferation