CNST

Gene Information

Official Symbol: CNST
Official Name: consortin, connexin sorting protein
Aliases and Previous Symbols: N/A
Entrez ID: 163882
UniProt: Q6PJW8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Required for targeting of connexins to the plasma membrane. {ECO:0000269|PubMed:19864490}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16444
Expression level (log2 read counts): 5.92

Expression Distribution

Screen	Score
Daidzin 10μM R06 exp280	1.75
A-366 10μM R03 exp115	1.9

positive regulation of Golgi to plasma membrane protein transport
connexin binding
regulation of Golgi to plasma membrane protein transport
phosphatase binding
positive regulation of protein localization to plasma membrane
positive regulation of protein localization to cell periphery
transport vesicle
regulation of protein localization to plasma membrane
negative regulation of phosphatase activity
negative regulation of dephosphorylation
regulation of protein localization to cell periphery
positive regulation of protein localization to membrane
trans-Golgi network
regulation of phosphatase activity
regulation of protein localization to membrane
regulation of dephosphorylation
positive regulation of cellular protein localization
positive regulation of protein transport
negative regulation of hydrolase activity
positive regulation of establishment of protein localization
regulation of cellular protein localization
regulation of vesicle-mediated transport
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
protein-containing complex
intracellular membrane-bounded organelle
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
negative regulation of catalytic activity
regulation of cellular localization
positive regulation of transport
regulation of protein localization
negative regulation of molecular function
regulation of hydrolase activity
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of transport
membrane