CPOX

Entrez Summary: The protein encoded by this gene is the sixth enzyme of the heme biosynthetic pathway. The encoded enzyme is soluble and found in the intermembrane space of mitochondria. This enzyme catalyzes the stepwise oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX, a precursor of heme. Defects in this gene are a cause of hereditary coproporphyria (HCP).[provided by RefSeq, Oct 2009].
UniProt Summary: Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 13/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	2/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

coproporphyrinogen oxidase activity
response to methylmercury
protoporphyrinogen IX biosynthetic process
protoporphyrinogen IX metabolic process
response to insecticide
heme biosynthetic process
structural constituent of eye lens
response to lead ion
porphyrin-containing compound biosynthetic process
tetrapyrrole biosynthetic process
heme metabolic process
response to arsenic-containing substance
response to iron ion
porphyrin-containing compound metabolic process
pigment biosynthetic process
tetrapyrrole metabolic process
pigment metabolic process
mitochondrial intermembrane space
cofactor biosynthetic process
response to metal ion
mitochondrial inner membrane
cofactor metabolic process
response to toxic substance
response to inorganic substance
protein homodimerization activity
oxidation-reduction process
heterocycle biosynthetic process
aromatic compound biosynthetic process
mitochondrion
organic cyclic compound biosynthetic process
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process