CPQ

Entrez Summary: N/A
UniProt Summary: Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Peptidase M20
Peptidase M28

metallodipeptidase activity
thyroid hormone generation
thyroid hormone metabolic process
carboxypeptidase activity
peptide catabolic process
tissue regeneration
phenol-containing compound metabolic process
regeneration
cellular modified amino acid metabolic process
hormone metabolic process
lysosome
developmental growth
growth
organic hydroxy compound metabolic process
wound healing
peptide metabolic process
regulation of hormone levels
response to wounding
intracellular membrane-bounded organelle
cellular amide metabolic process
protein homodimerization activity
Golgi apparatus
endoplasmic reticulum
organonitrogen compound catabolic process
proteolysis
extracellular space
tissue development
organic substance catabolic process
cellular catabolic process