CRB2

Gene Information

Official Symbol: CRB2
Official Name: crumbs cell polarity complex component 2
Aliases and Previous Symbols: N/A
Entrez ID: 286204
UniProt: Q5IJ48
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of a family of proteins that are components of the Crumbs cell polarity complex. In mammals, members of this family are thought to play a role in many cellular processes in early embryonic development. A similar protein in Drosophila determines apicobasal polarity in embryonic epithelial cells. Mutations in this gene are associated with focal segmental glomerulosclerosis 9, and with ventriculomegaly with cystic kidney disease. [provided by RefSeq, Aug 2016].
UniProt Summary: Apical polarity protein that plays a central role during the epithelial-to-mesenchymal transition (EMT) at gastrulation, when newly specified mesodermal cells move inside the embryo. Acts by promoting cell ingression, the process by which cells leave the epithelial epiblast and move inside the embryo to form a new tissue layer. The anisotropic distribution of CRB2 and MYH10/myosin-IIB at cell edges define which cells will ingress: cells with high apical CRB2 are probably extruded from the epiblast by neighboring cells with high levels of apical MYH10/myosin-IIB. Also required for maintenance of the apical polarity complex during development of the cortex. {ECO:0000250|UniProtKB:Q80YA8}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7713
Expression level (log2 read counts): 1.52

Expression Distribution

EGF
Laminin G 2
EGF CA

ingression involved in gastrulation with mouth forming second
aspartic-type endopeptidase inhibitor activity
notochord formation
notochord morphogenesis
maintenance of apical/basal cell polarity
maintenance of epithelial cell apical/basal polarity
cell migration involved in gastrulation
maintenance of cell polarity
notochord development
gastrulation with mouth forming second
positive regulation of BMP signaling pathway
regulation of gastrulation
establishment or maintenance of epithelial cell apical/basal polarity
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
positive regulation of epithelial to mesenchymal transition
establishment or maintenance of bipolar cell polarity
establishment or maintenance of apical/basal cell polarity
somitogenesis
mesoderm formation
mesoderm morphogenesis
somite development
regulation of epithelial to mesenchymal transition
regulation of BMP signaling pathway
segmentation
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
formation of primary germ layer
mesoderm development
regulation of embryonic development
gastrulation
ameboidal-type cell migration
establishment or maintenance of cell polarity
anterior/posterior pattern specification
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
negative regulation of endopeptidase activity
negative regulation of peptidase activity
cell-cell adhesion via plasma-membrane adhesion molecules
protein-containing complex binding
regulation of cellular response to growth factor stimulus
embryonic organ morphogenesis
apical plasma membrane