CREB3L3

Gene Information

Official Symbol: CREB3L3
Official Name: cAMP responsive element binding protein 3 like 3
Aliases and Previous Symbols: N/A
Entrez ID: 84699
UniProt: Q68CJ9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. {ECO:0000250, ECO:0000269|PubMed:11353085, ECO:0000269|PubMed:15800215, ECO:0000269|PubMed:16469704}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7755
Expression level (log2 read counts): -5.01

Expression Distribution

Screen	Score
Dinaciclib 0.007μM R07 exp355	-1.93
Aphidicolin 0.4μM R08 exp440	1.7
CI-1040 9.5μM R08 exp472	1.74
Momordin-Ic 10μM R08 exp506	2.03

bZIP 2
bZIP 1

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
cAMP response element binding
positive regulation of acute inflammatory response
positive regulation of transcription from RNA polymerase II promoter in response to stress
regulation of acute inflammatory response
transcription regulatory region sequence-specific DNA binding
endoplasmic reticulum unfolded protein response
regulation of transcription from RNA polymerase II promoter in response to stress
regulation of DNA-templated transcription in response to stress
cellular response to unfolded protein
positive regulation of inflammatory response
cellular response to topologically incorrect protein
response to unfolded protein
response to topologically incorrect protein
response to endoplasmic reticulum stress
RNA polymerase II regulatory region sequence-specific DNA binding
regulation of inflammatory response
DNA-binding transcription activator activity, RNA polymerase II-specific
positive regulation of defense response
protein heterodimerization activity
positive regulation of response to external stimulus
Golgi membrane
regulation of defense response
protein homodimerization activity
endoplasmic reticulum membrane
endoplasmic reticulum
regulation of response to external stimulus
positive regulation of transcription by RNA polymerase II
regulation of response to stress
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
cellular response to stress
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
membrane