CRKL
Gene Information
- Official Symbol: CRKL
- Official Name: CRK like proto-oncogene, adaptor protein
- Aliases and Previous Symbols: N/A
- Entrez ID: 1399
- UniProt: P46109
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009].
- UniProt Summary: May mediate the transduction of intracellular signals.
Pfam Domains GO Terms
Pfam Domains
| SH3 2 |
| SH2 |
| SH3 1 |
GO Terms
| helper T cell diapedesis |
| pharynx development |
| endothelin receptor signaling pathway |
| extrinsic component of postsynaptic membrane |
| cerebellar neuron development |
| helper T cell extravasation |
| regulation of skeletal muscle acetylcholine-gated channel clustering |
| diapedesis |
| parathyroid gland development |
| reelin-mediated signaling pathway |
| T cell extravasation |
| B cell apoptotic process |
| positive regulation of glial cell migration |
| regulation of neuromuscular junction development |
| regulation of receptor clustering |
| regulation of postsynaptic membrane organization |
| regulation of glial cell migration |
| retinoic acid receptor signaling pathway |
| lymphocyte apoptotic process |
| leukocyte apoptotic process |
| T cell migration |
| response to interleukin-7 |
| cellular response to interleukin-7 |
| acetylcholine receptor signaling pathway |
| cellular response to acetylcholine |
| response to acetylcholine |
| positive regulation of substrate adhesion-dependent cell spreading |
| cellular extravasation |
| postsynaptic signal transduction |
| phosphotyrosine residue binding |
| regulation of T cell migration |
| thymus development |
| regulation of cell adhesion mediated by integrin |
| regulation of substrate adhesion-dependent cell spreading |
| activation of MAPKK activity |
| SH3/SH2 adaptor activity |
| regulation of lymphocyte migration |
| positive regulation of Ras protein signal transduction |
| cranial skeletal system development |
| lymphocyte migration |
| positive regulation of gliogenesis |
| positive regulation of small GTPase mediated signal transduction |
| outflow tract morphogenesis |
| neuromuscular junction |
| central nervous system neuron development |
| fibroblast growth factor receptor signaling pathway |
| JNK cascade |
| hippocampus development |
| signal transduction involved in cellular response to ammonium ion |
| synapse assembly |
| regulation of postsynapse organization |
| activation of GTPase activity |
| cerebellum development |
| dendrite development |
| stress-activated MAPK cascade |
| cellular response to fibroblast growth factor stimulus |
| limbic system development |
| metencephalon development |
| response to fibroblast growth factor |
| regulation of gliogenesis |
| cerebral cortex development |
| establishment of cell polarity |
| neuron migration |
| positive regulation of cell-substrate adhesion |
| endocrine system development |
| cellular response to ammonium ion |
| digestive tract development |
| male gonad development |
| development of primary male sexual characteristics |
| single fertilization |
| stress-activated protein kinase signaling cascade |
| digestive system development |
| regulation of dendrite development |
| hindbrain development |
| cellular response to transforming growth factor beta stimulus |
| positive regulation of cell morphogenesis involved in differentiation |
| activation of MAPK activity |
| male sex differentiation |
| response to transforming growth factor beta |
| intracellular receptor signaling pathway |
| fertilization |
| pallium development |
| T cell receptor signaling pathway |
| central nervous system neuron differentiation |
| response to ammonium ion |
| regulation of protein localization to membrane |
| regulation of leukocyte migration |
| establishment or maintenance of cell polarity |
| cell chemotaxis |
| gonad development |
| positive regulation of ERK1 and ERK2 cascade |
| regulation of cell-substrate adhesion |
| development of primary sexual characteristics |
| anterior/posterior pattern specification |
| regulation of synapse organization |
| regulation of synapse structure or activity |
| regulation of Ras protein signal transduction |
| Ras protein signal transduction |
| heart morphogenesis |
| telencephalon development |
| positive regulation of MAP kinase activity |
| sex differentiation |
| synapse organization |
| regulation of ERK1 and ERK2 cascade |
| antigen receptor-mediated signaling pathway |
| regulation of cell morphogenesis involved in differentiation |
| cadherin binding |
| urogenital system development |
| small GTPase mediated signal transduction |
| activation of protein kinase activity |
| regionalization |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| regulation of small GTPase mediated signal transduction |
| MAPK cascade |
| leukocyte migration |
| forebrain development |
| signal transduction by protein phosphorylation |
| cellular response to drug |
| positive regulation of cell adhesion |
| negative regulation of protein phosphorylation |
| gland development |
| positive regulation of GTPase activity |
| regulation of cell growth |
| reproductive structure development |
| reproductive system development |
| pattern specification process |
| negative regulation of phosphorylation |
| immune response-activating cell surface receptor signaling pathway |
| synaptic signaling |
| positive regulation of neurogenesis |
| immune response-regulating cell surface receptor signaling pathway |
| regulation of GTPase activity |
| blood vessel development |
| regulation of cell morphogenesis |
| regulation of neuron projection development |
| positive regulation of cell migration |
| cellular response to growth factor stimulus |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| vasculature development |
| regulation of protein serine/threonine kinase activity |
| cardiovascular system development |
| positive regulation of cell motility |
| heart development |
| response to growth factor |
| positive regulation of protein kinase activity |
| positive regulation of nervous system development |
| positive regulation of cellular component movement |
| regulation of cellular protein localization |
| positive regulation of cell development |
| positive regulation of MAPK cascade |
| spermatogenesis |
| chemotaxis |
| taxis |
| positive regulation of locomotion |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| immune response-activating signal transduction |
| male gamete generation |
| positive regulation of kinase activity |
| negative regulation of protein modification process |
| protein-containing complex |
| immune response-regulating signaling pathway |
| cellular response to hormone stimulus |
| hematopoietic or lymphoid organ development |
| activation of immune response |
| immune system development |
| regulation of neuron differentiation |
| positive regulation of transferase activity |
| cellular response to nitrogen compound |
| neuron projection development |
| developmental process involved in reproduction |
| regulation of growth |
| cytokine-mediated signaling pathway |
| regulation of cell adhesion |
| gamete generation |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| enzyme linked receptor protein signaling pathway |
| brain development |
| regulation of MAPK cascade |
| positive regulation of hydrolase activity |
| head development |
| regulation of protein kinase activity |
| neuron development |
| regulation of neurogenesis |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| tube development |
| regulation of cell migration |
| positive regulation of immune response |
| circulatory system development |
| regulation of kinase activity |
| response to hormone |
| regulation of cell motility |
| regulation of cellular localization |
| positive regulation of cell population proliferation |
| apoptotic process |
| regulation of nervous system development |
| regulation of cell development |
| animal organ morphogenesis |
| cell migration |
| positive regulation of cell differentiation |
| protein phosphorylation |
| regulation of transferase activity |
| central nervous system development |
| regulation of locomotion |
| regulation of cellular component movement |
| multi-organism reproductive process |
| cellular response to cytokine stimulus |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| response to drug |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| programmed cell death |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| identical protein binding |
| localization of cell |
| cell motility |
| response to nitrogen compound |
| cell death |
| response to cytokine |
| negative regulation of protein metabolic process |
| cell-cell signaling |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of immune response |
| positive regulation of immune system process |
| cell projection organization |
| positive regulation of cellular component organization |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| regulation of hydrolase activity |
| phosphorylation |
| locomotion |
| G protein-coupled receptor signaling pathway |
| positive regulation of developmental process |
| RNA binding |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| generation of neurons |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| neurogenesis |
| cell development |
| positive regulation of signal transduction |
| regulation of immune system process |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| PFI-3 10μM R03 exp144 | -2.3 |
| TNF-alpha 44ng/ml R08 exp533 | -1.84 |
| Deguelin 0.05μM R02 exp69 | 1.92 |
| WYE-354 6μM R02 exp90 | 1.92 |
| Pyronaridine 1μM R06 exp295 | 1.93 |
| Taxol 0.004μM R03 exp103 | 2.56 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 285/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 16/28 |
| blood | 2/28 |
| bone | 5/26 |
| breast | 11/33 |
| central nervous system | 23/56 |
| cervix | 0/4 |
| colorectal | 8/17 |
| esophagus | 7/13 |
| fibroblast | 0/1 |
| gastric | 3/16 |
| kidney | 10/21 |
| liver | 7/20 |
| lung | 29/75 |
| lymphocyte | 0/16 |
| ovary | 11/26 |
| pancreas | 19/24 |
| peripheral nervous system | 6/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 16/24 |
| soft tissue | 3/9 |
| thyroid | 1/2 |
| upper aerodigestive | 9/22 |
| urinary tract | 16/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 13125
- Expression level (log2 read counts): 7.51
Expression Distribution
CRKL Expression in NALM6 Cells: 7.51
