CROCC

Entrez Summary: N/A
UniProt Summary: Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). {ECO:0000250|UniProtKB:Q8CJ40, ECO:0000269|PubMed:16203858, ECO:0000269|PubMed:27623382}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ONC212 0.15μM R08 exp513	-2.07
DABN racemic mixture R03 exp93	-1.86
5-Fluorouracil 20μM R00 exp2	-1.81
BI-6727 0.04μM R03 exp98	-1.72
Deguelin 0.15μM R05 exp209	-1.71
PF-06409577 20μM R07 exp389	1.72
Genistein 15μM R07 exp360	1.74
S-trityl-L-cysteine 0.5μM R05 exp243	1.76
CCT251545 20μM R07 exp326	1.81
FK-506 5μM R07 exp358	1.84
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	1.85
BRD2 inhibitor II 20μM R07 exp341	2.03
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	2.03
NMS-873 0.07μM R07 exp380	2.05
Lenalidomide 20μM R07 exp375	2.49

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ciliary basal body organization
positive regulation of protein localization to cilium
regulation of protein localization to cilium
ciliary rootlet
centriole-centriole cohesion
positive regulation of cilium assembly
epithelial structure maintenance
photoreceptor cell maintenance
kinesin binding
photoreceptor inner segment
positive regulation of organelle assembly
retina homeostasis
regulation of cilium assembly
centrosome cycle
microtubule organizing center organization
positive regulation of plasma membrane bounded cell projection assembly
structural constituent of cytoskeleton
centriole
tissue homeostasis
structural molecule activity
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
actin cytoskeleton
regulation of organelle assembly
actin binding
multicellular organismal homeostasis
positive regulation of cellular protein localization
anatomical structure homeostasis
establishment of organelle localization
cilium organization
positive regulation of cell projection organization
microtubule cytoskeleton organization
centrosome
positive regulation of cellular component biogenesis
regulation of cellular protein localization
organelle localization
positive regulation of organelle organization
microtubule-based process
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization