CRTAP

Entrez Summary: The protein encoded by this gene is similar to the chicken and mouse CRTAP genes. The encoded protein is a scaffolding protein that may influence the activity of at least one member of the cytohesin/ARNO family in response to specific cellular stimuli. Defects in this gene are associated with osteogenesis imperfecta, a connective tissue disorder characterized by bone fragility and low bone mass. [provided by RefSeq, Jul 2008].
UniProt Summary: Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues. {ECO:0000269|PubMed:17055431}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

peptidyl-proline hydroxylation to 3-hydroxy-L-proline
negative regulation of post-translational protein modification
regulation of post-translational protein modification
peptidyl-proline hydroxylation
protein hydroxylation
chaperone-mediated protein folding
peptidyl-proline modification
protein stabilization
cellular modified amino acid metabolic process
protein folding
regulation of protein stability
endoplasmic reticulum lumen
spermatogenesis
male gamete generation
negative regulation of protein modification process
protein-containing complex
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
peptidyl-amino acid modification
multi-organism reproductive process
endoplasmic reticulum
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
reproductive process
reproduction
extracellular space
regulation of protein modification process