CSNK2A3

Entrez Summary: N/A
UniProt Summary: Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down- regulating expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer development and progression. {ECO:0000269|PubMed:20625391}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Pkinase
Pkinase Tyr

protein kinase CK2 complex
peptidyl-threonine phosphorylation
peptidyl-threonine modification
positive regulation of cell growth
peptidyl-serine phosphorylation
peptidyl-serine modification
positive regulation of protein catabolic process
positive regulation of growth
protein serine/threonine kinase activity
regulation of protein catabolic process
regulation of cell growth
positive regulation of catabolic process
regulation of growth
peptidyl-amino acid modification
positive regulation of cell population proliferation
protein phosphorylation
regulation of catabolic process
regulation of cell cycle
phosphorylation
ATP binding
regulation of cell population proliferation
positive regulation of protein metabolic process