CSRP2

Entrez Summary: N/A
UniProt Summary: Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Fluvastatin 2.2μM R06 exp282	-1.76
R-DABN 8μM R03 exp111	1.73

actinin binding
structural constituent of muscle
sarcomere organization
myofibril assembly
cellular component assembly involved in morphogenesis
actomyosin structure organization
Z disc
striated muscle cell development
muscle cell development
striated muscle cell differentiation
muscle cell differentiation
muscle tissue development
focal adhesion
supramolecular fiber organization
muscle structure development
actin cytoskeleton organization
actin filament-based process
organelle assembly
molecular function
cellular component morphogenesis
anatomical structure formation involved in morphogenesis
cytoskeleton organization
cell development
tissue development