CST9

Entrez Summary: N/A
UniProt Summary: May be involved in testis development (By similarity). May play a role in hematopoietic differentiation or inflammation (PubMed:12535658). Has immunomodulatory and antimicrobial functions against Francisella tularensis, a Gram-negative bacteria (PubMed:23922243). {ECO:0000250|UniProtKB:Q9Z0H6, ECO:0000269|PubMed:12535658, ECO:0000269|PubMed:23922243}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Aminopterin 0.005μM R07 exp335	-1.7
2-Methoxyestradiol 0.2μM R01 exp40	1.75
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.79

cysteine-type endopeptidase inhibitor activity
antimicrobial humoral response
negative regulation of endopeptidase activity
negative regulation of peptidase activity
humoral immune response
negative regulation of proteolysis
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
regulation of proteolysis
negative regulation of catalytic activity
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
regulation of hydrolase activity
response to other organism
response to external biotic stimulus
response to biotic stimulus
immune response
extracellular region