CTSH
Gene Information
- Official Symbol: CTSH
- Official Name: cathepsin H
- Aliases and Previous Symbols: N/A
- Entrez ID: 1512
- UniProt: P09668
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016].
- UniProt Summary: Important for the overall degradation of proteins in lysosomes.
Pfam Domains GO Terms
Pfam Domains
| Peptidase C1 |
| Inhibitor I29 |
GO Terms
| HLA-A specific activating MHC class I receptor activity |
| neuropeptide catabolic process |
| dichotomous subdivision of terminal units involved in lung branching |
| alveolar lamellar body |
| bradykinin catabolic process |
| multivesicular body lumen |
| thyroid hormone binding |
| dichotomous subdivision of an epithelial terminal unit |
| surfactant homeostasis |
| chemical homeostasis within a tissue |
| cellular response to thyroid hormone stimulus |
| cysteine-type endopeptidase activator activity involved in apoptotic process |
| T cell mediated cytotoxicity |
| epithelial tube branching involved in lung morphogenesis |
| response to thyroid hormone |
| aminopeptidase activity |
| ERK1 and ERK2 cascade |
| cysteine-type peptidase activity |
| peptide catabolic process |
| membrane protein proteolysis |
| leukocyte mediated cytotoxicity |
| zymogen activation |
| T cell mediated immunity |
| lung morphogenesis |
| protein destabilization |
| tertiary granule lumen |
| cytoplasmic ribonucleoprotein granule |
| endopeptidase activity |
| peptidase activity |
| metanephros development |
| activation of cysteine-type endopeptidase activity involved in apoptotic process |
| cell killing |
| cysteine-type endopeptidase activity |
| response to retinoic acid |
| secretory granule lumen |
| ficolin-1-rich granule lumen |
| branching morphogenesis of an epithelial tube |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| positive regulation of epithelial cell migration |
| drug catabolic process |
| positive regulation of cysteine-type endopeptidase activity |
| protein processing |
| morphogenesis of a branching epithelium |
| serine-type endopeptidase activity |
| positive regulation of angiogenesis |
| morphogenesis of a branching structure |
| lung development |
| respiratory tube development |
| positive regulation of endopeptidase activity |
| positive regulation of apoptotic signaling pathway |
| positive regulation of vasculature development |
| tissue homeostasis |
| positive regulation of peptidase activity |
| respiratory system development |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| antigen processing and presentation |
| regulation of epithelial cell migration |
| protein maturation |
| regulation of cysteine-type endopeptidase activity |
| lysosome |
| lymphocyte mediated immunity |
| kidney development |
| adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| renal system development |
| regulation of angiogenesis |
| regulation of protein stability |
| epithelial tube morphogenesis |
| urogenital system development |
| regulation of vasculature development |
| multicellular organismal homeostasis |
| anatomical structure homeostasis |
| response to acid chemical |
| positive regulation of proteolysis |
| collagen-containing extracellular matrix |
| MAPK cascade |
| signal transduction by protein phosphorylation |
| regulation of apoptotic signaling pathway |
| regulation of endopeptidase activity |
| morphogenesis of an epithelium |
| regulation of peptidase activity |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| positive regulation of cell migration |
| drug metabolic process |
| neutrophil activation |
| granulocyte activation |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| positive regulation of cell motility |
| peptide metabolic process |
| positive regulation of cellular component movement |
| positive regulation of locomotion |
| tissue morphogenesis |
| myeloid leukocyte activation |
| proteolysis involved in cellular protein catabolic process |
| immune response-regulating signaling pathway |
| cellular response to hormone stimulus |
| adaptive immune response |
| cellular protein catabolic process |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| tube morphogenesis |
| protein catabolic process |
| intracellular membrane-bounded organelle |
| positive regulation of cell death |
| regulated exocytosis |
| regulation of proteolysis |
| leukocyte mediated immunity |
| positive regulation of hydrolase activity |
| cellular amide metabolic process |
| exocytosis |
| tube development |
| regulation of cell migration |
| response to lipid |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| cellular macromolecule catabolic process |
| response to hormone |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| apoptotic process |
| leukocyte activation |
| animal organ morphogenesis |
| protein phosphorylation |
| regulation of locomotion |
| regulation of cellular component movement |
| negative regulation of cell death |
| secretion by cell |
| export from cell |
| macromolecule catabolic process |
| programmed cell death |
| regulation of anatomical structure morphogenesis |
| organonitrogen compound catabolic process |
| cell activation |
| cell death |
| immune effector process |
| chemical homeostasis |
| epithelium development |
| secretion |
| regulation of immune response |
| cellular response to endogenous stimulus |
| proteolysis |
| regulation of hydrolase activity |
| phosphorylation |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| response to endogenous stimulus |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| homeostatic process |
| regulation of immune system process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| organic substance catabolic process |
| positive regulation of molecular function |
| cellular catabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| immune response |
| extracellular region |
| vesicle-mediated transport |
| positive regulation of gene expression |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10400
- Expression level (log2 read counts): 1.08
Expression Distribution
CTSH Expression in NALM6 Cells: 1.08
